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CELESTIAL-TNCLL: ongoing Phase III study of sonrotoclax + zanubrutinib vs ven + obi for TN CLL [Video]

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Blood Cancer

CELESTIAL-TNCLL: ongoing Phase III study of sonrotoclax + zanubrutinib vs ven + obi for TN CLL

Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, shares details of CELESTIAL-TNCLL (NCT06073821), an ongoing Phase III study comparing sonrotoclax plus zanubrutinib versus standard-of-care venetoclax (ven) plus obinutuzumab (obi) for treatment-naïve (TN) chronic lymphocytic leukemia (CLL). Dr Shadman hopes that combining sonrotoclax and zanubrutinib will confer a survival advantage and provide patients with a novel fixed-duration chemotherapy-free treatment option. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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