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Lung Cancer

Jerry Remy, iconic Boston Red Sox broadcaster, passes away at 68 [Video]

Longtime Boston Red Sox broadcaster Jerry Remy has passed away at 68 years old. The news was first reported by WCVB-TV.

Remy had endured repeated struggles with lung cancer for years, undergoing treatment seven times for the disease. Earlier this year, he left the NESN broadcast booth after experiencing shortness of breath and did not return for the remainder of the Red Sox’s 2021 season.

Following a 10-year career as a major-league infielder — six of those seasons with Boston — Remy became a broadcaster in 1988, doing color commentary for Red Sox telecasts on NESN. Calling games didn’t come naturally to him at first, as he explained to the Boston Globe‘s Gordon Edes in 2004.

“I remember the first game I worked in spring training. I didn’t know the score. I didn’t know the count,” said Remy. “I knew baseball, but I knew nothing about TV. I was totally lost. I remember my first …

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Lung Cancer

Oncotarget | Effects of Metformin and Rapamycin in Pancreatic Cancer [Video]

Oncotarget published this trending research paper on May 26, 2020, entitled, "An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma" by researchers from the Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD; The Skip Viragh Center for Pancreas Cancer at Johns Hopkins, Baltimore, MD; Virginia Piper Cancer Center at HonorHealth, Scottsdale, AZ; Molecular Medicine Division, Translational Genomics Research Institute (TGen), Phoenix, AZ; Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai City, China; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.Abstract:Purpose: Metformin combined with the mTOR inhibitor rapamycin showed potential synergistic anti-tumor activity in preclinical studies in pancreatic ductal adenocarcinoma (PDA). This phase 1b study (NCT02048384) was conducted to evaluate the feasibility and activity of metformin +/– rapamycin in the maintenance setting for unselected patients with metastatic PDA (mPDA) treated with chemotherapy.Materials and Methods: Eligible patients with stable or responding mPDA after ≥ 6 months on chemotherapy were randomized 1:1 to metformin alone (Arm A) or with rapamycin (Arm B), stratified by prior treatment with FOLFIRINOX. Fluorodeoxyglucose (FDG) PET scans and peripheral blood mononuclear cells were obtained for exploratory analyses.Results: 22 subjects (11 per arm) received treatment per protocol. Median PFS/OS were 3.5 and 13.2 months respectively, with 2 year OS rate of 37%; there were no differences between arms. No responses were observed by RECIST; however, decreases in FDG avidity and/or CA19-9 were observed in several long-term survivors. Treatment related adverse events of Grade ≥ 3 occurred in 0% vs 27% of patients in Arm A vs B and were asymptomatic hematologic or electrolyte abnormalities that were not clinically significant. Improved survival was associated with low baseline neutrophil: lymphocyte ratio, baseline lack of assessable disease by PET, and greater expansion of dendritic cells following treatment.Conclusions: Metformin +/– rapamycin maintenance for mPDA was well-tolerated and several patients achieved stable disease associated with exceptionally long survival. Further prospective studies are needed to clarify the role of these agents in the maintenance setting and to enhance patient selection for such approaches.Press release - https://www.oncotarget.com/news/pr/an-exploratory-study-of-metformin-and-rapamycin-as-maintenance-therapy/Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27586DOI - https://doi.org/10.18632/oncotarget.27586Full text - https://www.oncotarget.com/article/27586/text/Correspondence to - Dung T. Le - dle@jhmi.edu Keywords - pancreatic cancer, mTOR inhibition, maintenance therapy, metformin, rapamycinAbout OncotargetOncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:SoundCloud - https://soundcloud.com/oncotargetFacebook - https://www.facebook.com/Oncotarget/Twitter - https://twitter.com/oncotargetInstagram - https://www.instagram.com/oncotargetjrnl/YouTube - https://www.youtube.com/c/OncotargetYouTube/LinkedIn - https://www.linkedin.com/company/oncotargetPinterest - https://www.pinterest.com/oncotarget/Reddit - https://www.reddit.com/user/Oncotarget/Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnlsMedia ContactMEDIA@IMPACTJOURNALS.COM18009220957

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Lung Cancer

Live Study With Me For Finals | Pomodoro 50/10 | Quiet Study Session [Video]

✨⏰📚⬇️ CLICK BELOW FOR SCHEDULE ⬇️📚⏰✨ ✨ Live Study With Me Pomodoro✨ Seven Hours | 50/10✨ Hudson River Views in Manhattan✨ Current subscriber count → 2,010Hi friends :)Study with me as I work towards finals, while completing a PhD in Musicology at All Hallows College, DCU (Ireland). I'm currently living in Manhattan, NY and I always, ALWAYS work better when studying with other pals and peeps, so thank you for studying with me today. 🟢 Today's study with me is four sessions long.🟢 We start at 9:00am and we finish at 2:00pm.🟢 The timer/session is on the screen, and a bell will ring at the beginning and end of each session and break. 09.00 - 09.50 Session 109.50 - 10:00 Tea Break10.00 - 10.50 Session 210.50 - 11.00 Tea Break11.00 - 11.50 Session 311.50 - 12.00 Tea Break 12.00 - 12.50 Session 4 12.50 - 13.00 LUNCH, GREAT SUCCESS!I'm really enjoying the winter holiday vibes in Manhattan right now so I've got some candles lit, hot coffee at. hand and a crackling fire playlist on in the background.Let me know in the comments - what are you planning to study today? 🤓Hugs,Holly x_________________________________________________✨ FAQ ✨How old are you?I'm 29 and 13 months old.Where are you based?I'm Irish but have recently moved to MANHATTAN, BABY!!!!!What type of cancer are you getting treatment for?Stage IV oesophageal adenocarcinomaWhat drug are you on?An immunotherapy drug, called Nivolumab (Opdivo)What type of PhD research are you carrying out?Historical research into records of children's musical culture in IrelandWhich university are you studying at?All Hallows, College, Dublin City University____________________________✨ Say hi on Instagram :) or email @enquiries.hollyjane@gmail.com