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Skin Cancer

Research on “molecular drills” of skin cancer cells offers hope for treatment [Video]

Research on “molecular drills” of skin cancer cells offers hope for treatment

Institute of Cancer Research in London Gene isolates that allow melanoma cells to spread
#Research #moleculardrills #skin #cancercells
The cancer cells of the skin produce “molecular forests” to penetrate healthy tissues and spread around the body, according to research that increases the prospect of new therapies for the disease. The researchers used robotic microscopy to capture the formation of exercises by melanoma cells which were cultivated in 3D material of the skin in the laboratory. The exercises help the tumor cells to fix and puncture the holes in the cells and the surrounding structures, allowing cancer to move beyond the site where it forms and reaches other tissues and organs. “This is the first time that this type of change in cell form has been associated with any type of metastatic cancer,” said Chris Bakal, professor of cancer morphodynamics at the London Cancer Research Institute. Melanoma levels have more than doubled in the United Kingdom since the 1990s, with more than 16,000 people newly diagnosed with the disease each year. At first, tumors can often be eliminated by surgeons, but cancer becomes more difficult to treat because it spreads to other parts of the body. Bakal and his colleagues cultivated melanoma cells in a 3D matrix rich in collagen, one of the main proteins found in the skin. By exhausting the genes in cancer cells one by one, they discovered a particular gene, Arhgef9, which was crucial for the formation of molecular exercises. The gene is found in all human cells, but in adults, it tends to be activated in brain cells to help them establish new connections. Much earlier in human development, the gene allows neurons to produce their own drill structures, which help cells spread through the body and wire the nervous system. By writing in the journal ISCIENCE, the researchers describe how the deactivation of the ARHGEF9 gene in the melanoma cells has destabilized molecular exercises so that cancer can no longer fix and engage in neighboring tissues. The observation increases hopes of new therapies for melanoma and possibly other cancers, such as neuroblastoma, which can spread in the same way. Although the mutations of the ARHGEF9 gene are linked to a wide range of neurological disorders, the gene is considered more important during early development than to adulthood. If this is the case, the development of drugs to inhibit the gene could block the spread of melanoma without serious side effects. “We believe that the disarmament of the exercise is likely to have a general demand,” said Bakal, although it suspects that the process will not be relevant for all melanomas. Because the gene is very active in this metastatic

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Skin Cancer

Olympic Gold Medalist Diagnosed with Melanoma Skin Cancer | Cancer Story [Video]

Cate Campbell diagnosed with Melanoma cancer in August 2022. Cate Campbell is an Australian National Swimming Champion and Olympic Gold Medalist. This is her story.#cancerstory #melanomaawareness #melanoma My cancer diagnosis story: https://youtu.be/PYsuoN3z-5UMy cancer removal surgery story: https://youtu.be/oOIvyqDSfUcCate Campbell article: https://melanoma.org.au/news/team/cate-campbell/Hugh Jackman article: https://www.skincancer.org/blog/is-basal-cell-carcinoma-serious/Email me your diagnosis story: themelanomamom@gmail.com