Categories
Pancreatic Cancer

Restoration of Wild-Type TP53 in Pancreatic Cancer | Aging-US [Video]

Aging (Aging-US) published this research paper as the cover for Volume 14, Issue 8, entitled, “Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties” by researchers the Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC; Department of Biomedical and Neuromotor Sciences, Università di Bologna, Bologna, Italy; Department of Medicine and Surgery, Re.Mo.Bio.S. Laboratory, Anatomy Section, University of Parma, Parma, Italy; Department of Molecular Physiology and Neurobiology, University of Wroclaw, Wroclaw, Poland.DOI – https://doi.org/10.18632/aging.204038Corresponding author – James A. McCubrey – mccubreyj@ecu.eduAbstractTP53 is a master regulator of many signaling and apoptotic pathways involved in: aging, cell cycle progression, gene regulation, growth, apoptosis, cellular senescence, DNA repair, drug resistance, malignant transformation, metastasis, and metabolism. Most pancreatic cancers are classified as pancreatic ductal adenocarcinomas (PDAC). The tumor suppressor gene TP53 is mutated frequently (50–75%) in PDAC. Different types of TP53 mutations have been observed including gain of function (GOF) point mutations and various deletions of the TP53 gene resulting in lack of the protein expression. Most PDACs have point mutations at the KRAS gene which result in constitutive activation of KRas and multiple downstream signaling pathways. It has been difficult to develop specific KRas inhibitors and/or methods that result in recovery of functional TP53 activity. To further elucidate the roles of TP53 in drug-resistance of pancreatic cancer cells, we introduced wild-type (WT) TP53 or a control vector into two different PDAC cell lines. Introduction of WT-TP53 increased the sensitivity of the cells to multiple chemotherapeutic drugs, signal transduction inhibitors, drugs and nutraceuticals and influenced key metabolic properties of the cells. Therefore, TP53 is a key molecule which is critical in drug sensitivity and metabolism of PDAC.Sign up for free Altmetric alerts about this article – https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204038Keywords – aging, TP53, targeted therapy, PDAC, metabolic properties, chemotherapeutic drugs About Aging-USLaunched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.Please visit our website at http://www.Aging-US.com​​ or connect with us:SoundCloud – https://soundcloud.com/Aging-UsFacebook – https://www.facebook.com/AgingUS/Twitter – https://twitter.com/AgingJrnlInstagram – https://www.instagram.com/agingjrnl/YouTube – https://www.youtube.com/agingus​LinkedIn – https://www.linkedin.com/company/aging/Pinterest – https://www.pinterest.com/AgingUS/Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​Media Contact18009220957MEDIA@IMPACTJOURNALS.COM

Categories
Breast Cancer

The Wellness Exchange: Women’s Health with Dr. Audrey Gutierrez [Video]

Dr. Audrey Gutierrez from South Texas Health System stopped by to discuss women’s health. The doctor highlighted overall cardiac health issues women face. Other health topics briefly covered included mammograms, annual checkups, pregnancy, and menopause.____________________________DISCLAIMER:The information contained in the video represents the views and opinions of the interviewee and does not necessarily represent the views or opinions of the County of Hidalgo. The video content has been made available for informational and educational purposes only. The County of Hidalgo does not make any representation or warranties with respect to the accuracy, applicability, fitness, or completeness of the content of the video and does not endorse, warrant the performance, effectiveness, or applicability of any sites listed or linked to in this video.The content of the video is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen on this YouTube Channel.____________________________FOR COUNTY EMPLOYEES ONLY:Website: https://www.hidalgocountywellnessprogram.com/Facebook Group: https://www.facebook.com/groups/hidalgocountyemployeewellness

Categories
Skin Cancer

MINERAL VS. CHEMICAL SUNSCREEN | ARE THEY SAFE ? [Video]

How can the sun, the energy source of all life on this planet, be harmful to us? Sure, you can have too much sunlight, and that’s no good, and that is the key to the whole issue. We want just the right amount. For questions or additional information contact me at www.aglaiaesthetics.comIN THIS VIDEO: SPF 30 is the most common level for most people and skin types. No sunscreen can block all UV rays, but what we do know is: SPF 15 blocks 93% of UVB rays, SPF 30 blocks 97% of UVB rays and SPF 50 blocks 98% of UVB rays. However 50+ have many damaging chemicals. Products with SPF values greater than 50+ also tend to give users a false sense of security. High SPF sunscreens not only overpromise protection but, according to the Food and Drug Administration, may also overexpose consumers to UVA rays and raise their risk of cancer.Ultraviolet (UV) rays carry ionizing radiation, which causes a chemical reaction in the body. There are three types of UV rays: UVA, UVB, and UVC. UVA rays penetrate the top layers of the skin, reaching deeper layers with the potential to cause long-term damage, like premature aging and skin cancer. UVB rays affect the top layers of skin and are responsible for sunburn. UVC rays are absorbed by the ozone layer before ever reaching the earth, and are not a hazard to our health.ACTIVE SUNSCREEN INGREDIENTS TO BE AWAREOxybenzoneOctinoxate (Octyl methoxycinnamate)HomosalateOctisalateOctinoxateOctocryleneAvobenzoneRetinyl PalmitateTIMESTAMPS0:00 – Pre Introduction1:00 – Introduction and Vit. D2:05 – Intro on Mineral and Chemical Sunscreen3:42 – The Sun and UV Radiation Theory4:40 – SPF 15 or SPF 50?6:15 – Two Types of Sunscreens7:48 – Explanation on Chemical Ingredients13:22 – How Does it Work?14:40 – Titanium Dioxide and Zinc Oxide16:55 – How to Protect Your Skin With No Sunscreen17:35 – ConclusionCHECK SOME GREAT PRODUCT LINKS BELOW – I PERSONALLY RESEARCHED THE BEST PRODUCTS AND VALUEAn NRF2 anti-oxidant taken internally and externally so powerful it’s being studied for life-extension applications and how you can use it to take years off the appearance of your skin. Give me some comments below and if you’re not already subscribe please subscribe, it really means a lot to me and I can’t wait to see you in the next tutorial.EXTERNAL – Gene Activation Skin Care – Your skin… it’s the largest organ of the body… here is an intro to biohacking your skin! https://rfres.com/d/swaKtYINTERNAL – NUTRIGENOMIC BioHacking and Gene Activation – https://rfres.com/d/2Q1aJh CAN – Pure evening Primrose – https://amzn.to/3diqeHRUSA – Pure Evening Primrose – https://amzn.to/3dbFvdmCAN – Radha Rosehip oil https://amzn.to/3okkv9TUSA – Radha Rosehip oil https://amzn.to/3otJ9VLCAN – Ordinary SPF 15 Mineral Sunscreen https://amzn.to/3tWTmQHUSA – Ordinary SPF 15 Mineral Sunscreen https://amzn.to/3FUeAkwCAN – Ordinary SPF 30 Mineral Sunscreen https://amzn.to/3KF36F2USA – SPF 30 Mineral Sunscreen https://amzn.to/33Ex4sqCAN – After Sun Aloe Lotion https://amzn.to/3tWUfZxUSA – After Sun Aloe Lotion https://amzn.to/3rCpNRyABOUT: In this video Maria from Aglaia Esthetics, will answers the burning question: HOW TO CHOOSE THE BEST SUNSCREEN FOR YOUR SKIN TYPECOPYRIGHT Disclaimer: This tutorial is not sponsored or influenced by any brand 🙂 Having the opportunity to create and share enlightening content is another reason I’m so grateful for YouTube as a platform, the opportunities life presents us, and your love and support as part of my YouTube family!! In some cases, I post affiliate links that ultimately support the content provided. By no means should you ever feel obligated to use these links, but know that if you do purchase through any of them, you are contributing to spreading the message of positivity, self-love, and self-care that is expressed on this channel. Thank you always! I STRONGLY advise to seek medical advice and to take caution when using these products. I am not a doctor or a medical professional. The information on this video is meant for educational purposes only. This information and products mentioned are NOT to diagnose, treat, cure or prevent any disease. Statements on this video have not been evaluated by the FDA. PLEASE consult your physician first.https://www.aglaiaesthetics.com https://www.facebook.com/Aglaia-Esthetics-Distance-Learning-Online-320403271400900/ https://www.instagram.com/aglaiaesthetics/#MineralSunscreen #ChemicalSunscreen #AglaiaEshetics

Categories
Lung Cancer

Smokers Who Do This Don’t Get Lung Cancer [Video]

00:00 INTRO00:27 SERIOUS01:09 PARADOXES02:11 DIFFERENT03:27 ASSOCIATIONS04:57 THE HACK06:46 WHY?11:32 TAKEAWAYSJOIN OUR COMMUNITY:Reddit ▶ https://www.reddit.com/r/TheLongLived/FOR GENETIC ANALYSIS & CONSULTATIONS:Website ▶ https://www.leoandlongevity.comTO READ MY ARTICLES:Blog ▶ https://www.leoandlongevity.com/blogTO FOLLOW ME ON SOCIAL MEDIA: Instagram ▶ https://www.instagram.com/leoandlongevityTwitter ▶ https://www.twitter.com/leoandlongevityFacebook ▶ https://www.facebook.com/LeoLongevityGorilla Mind 10% Discount: LEOAffiliate Link: https://gorillamind.com/?rfsn=5750379.0e4babc

Categories
Skin Cancer

SIGNS OF SKIN CANCER | PREVENTION [Video]

Skin cancer affects people of all skin tones, including those with darker complexions. Skin cancer begins in your skin’s top layer — the epidermis. For questions or additional information contact me at: www.AglaiaEsthetics.comIN THIS VIDEO: Where your skin cancer begins determines its type and your treatment options. Skin cancer develops primarily on areas of sun-exposed skin, including the scalp, face, lips, ears, neck, chest, arms and hands, and on the legs in women. But it can also form on areas that rarely see the light of day — your palms, beneath your fingernails or toenails, and your genital area.TYPES OF SKIN CANCER:1. Basal cell carcinoma 2. Squamous cell carcinoma 3. Melanoma signs and symptomsLESS COMMON SKIN CANCER1. Kaposi sarcoma2. Merkel cell carcinoma3. Sebaceous gland carcinomaFactors that may increase your risk of skin cancer include:• Fair skin. • A history of sunburns. • Excessive sun exposure. • Sunny or high-altitude climates. • Moles. • Precancerous skin lesions. • A family history of skin cancer. • A personal history of skin cancer. • A weakened immune system. • Exposure to radiation. Most skin cancers are preventable. To protect yourself, follow these skin cancer prevention tips:• Avoid the sun during the middle of the day. • Wear sunscreen year-round. • Wear protective clothing. • Avoid tanning beds. • Be aware of sun-sensitizing medications. • Check your skin regularly and report changes to your doctor. TIMESTAMPS0:00 – Pre Introduction0:40 – Introduction1:57 – Where do you get skin cancer?2:30 – Basal Cell Carcinoma3:00 – Squamous Cell Carcinoma3:25 – Melanoma4:44 – Kaposi Sarcoma5:21 – Merkel Cell Carcinoma5:46 – Sebaceous Cell Carcinoma6:15 – UVR Damage and Tanning Beds8:03 – Check Your Moles Regularly8:25 – Actinic Keratosis8:50 – History of Skin Cancer9:26 – Prevention Steps12:38 – ConclusionCHECK SOME GREAT PRODUCT LINKS BELOW – I PERSONALLY RESEARCHED THE BEST PRODUCTS AND VALUEAn NRF2 anti-oxidant taken internally and externally so powerful it’s being studied for life-extension applications and how you can use it to take years off the appearance of your skin. Give me some comments below and if you’re not already subscribe please subscribe, it really means a lot to me and I can’t wait to see you in the next tutorial.EXTERNAL – Gene Activation Skin Care – Your skin… it’s the largest organ of the body… here is an intro to biohacking your skin! https://rfres.com/d/swaKtYINTERNAL – NUTRIGENOMIC BioHacking and Gene Activation – https://rfres.com/d/2Q1aJh This video is not sponsored. Links below contain affiliates.CAN – Best Mineral Makeup – https://amzn.to/38hxFfM USA – Best Mineral Make up – https://amzn.to/39yaxeACAN – Pure evening Primrose – https://amzn.to/3diqeHRUSA – Pure Evening Primrose – https://amzn.to/3dbFvdmCAN – SPF 15 Aveeno https://amzn.to/3GpmOCkUSA – SPF 15 Aveeno https://amzn.to/3thuZgbABOUT: In this video Maria from Aglaia Esthetics, will answers the burning question: HOW to determine different types of skin cancer. I hope this tutorial has given you an insight and clarity on this important subject on how to prevent and protect your skin both form getting skin cancer and aging.COPYRIGHT Disclaimer: This tutorial is not sponsored or influenced by any brand 🙂 Having the opportunity to create and share enlightening content is another reason I’m so grateful for YouTube as a platform, the opportunities life presents us, and your love and support as part of my YouTube family!! In some cases, I post affiliate links that ultimately support the content provided. By no means should you ever feel obligated to use these links, but know that if you do purchase through any of them, you are contributing to spreading the message of positivity, self-love, and self-care that is expressed on this channel. Your love, support, and involvement in this YouTube family is very much appreciated. Thank you always! MariaI STRONGLY advise to seek medical advice and to take caution when using these products. I am not a doctor or a medical professional. The information on this video is meant for educational purposes only. This information and products mentioned are NOT to diagnose, treat, cure or prevent any disease. Statements on this video have not been evaluated by the FDA. PLEASE consult your physician first.https://www.aglaiaesthetics.com https://www.facebook.com/Aglaia-Esthetics-Distance-Learning-Online-320403271400900/ https://www.instagram.com/aglaiaesthetics/#SkinCancer #Prevention #AglaiaEsthetics

Categories
Lung Cancer

theZoomer on Lung Cancer [Video]

Libby Znaimer is joined by scientists, oncologists, survivors and advocates to address the stigma of lung cancer, and discuss the emergence of a new pillar of cancer therapy: immunotherapy.Our guests:Dr. Stephanie Snow, Pres. Lung Cancer CanadaDr. Barbara Melosky, Prof. of Medicine, UBC, Lung Cancer Program Leader, BC Cancer Integrative Oncology ResearchDr. Paul Wheatley-Price, Oncologist, Dept. of Medicine, The Ottawa Hospital – L’Hôpital d’Ottawa Cancer CentreDebi Lascelle, Lung Cancer SurvivorHosted by Libby Znaimer and Marissa Lennox, theZoomer is a sharp, relevant and intelligent take on the world from a uniquely “Zoomer” aka “Boomer with Zip” point of view, airing Mondays at 10pm ET and Fridays at 11pm ET on VisionTV. https://visiontv.ca/shows/thezoomer

Categories
Colon Cancer

Why do you need a Colonoscopy? To make sure you don’t die of Colon Cancer! [Video]

See all the Healthcast at https://www.biobalancehealth.com/healthcast-blog/Colon Cancer is the third most common malignancy in the US and is something you don’t want to get and there are many ways to test you to see if you have pre-cancer, cancer or polyps which are also risks for cancer. They advertise these tests that you can do yourself by testing your own poop. My family physician daughter advises our patients that those tests do not adequately test for pre-cancer or colon cancer. They might find a cancer, but they will miss more than they find.90 % of Colon cancers are diagnosed after age 50. The incidence of colon cancer in the US is 4.2% and if there is a family history in a close relative before the age of 50, the incidence doubles to 8.4%. What makes a person high risk other than family history?• Personal history of adenomas (polyps) on colonoscopy• Large adenomas (more than 1 cm)• Multiple adenomas• Flat adenomas that are difficult to remove• Adenomas that have precancerous lesions• Ulcerative colitis increased the risk dramaticallyColon cancer can progress without many signs therefore it is important to get a colonoscopy under sedation when you are 50. After that, depending on your risk factors your doctor will tell you how often you will need surveillance. Now, as for the other tests that you can do at home in between colonoscopies, my favorite is the stool guaiac test looking for microscopic blood. This blood doesn’t look red and is not visible. I used to do vaginal and rectal exams at the same time during gyn exams and would test the stool on my glove for microscopic blood (the guaiac test) by taking the sample, smearing it on a card and dropping a drop of developer on it. If it turns blue, there is microscopic blood and possibly cancer. I rarely had a positive, but if I did, a referral was made for a colonoscopy, and it was about 50% positive in my testing experience. The same test at home can be done on 3 successive stool samples and this should be a good test to do at home. They have just come out with a FIT test (fecal immunochemical test) that tests for DNA mutations of colon cells. It is more sensitive and accurate than Guaiac test but not as accurate as a colonoscopy. It was determined that the best frequency was 2 x a year.As it stands the colonoscopy is the best test, but it requires sedation and an invasive procedure, however low risk. I still recommend a colonoscopy at 50 and every 10 years thereafter. Soon I am sure this FIT do at home test will be recommended frequently to lower the number of Colonoscopies, as a matter of cost saving. High risk individuals should continue with colonoscopies until the recommendations change. Prevention is my recommendation:• Eat a fresh salad every day• Drink more than 10 -8 oz glasses of water daily• Alcohol and sodas to a minimum.• Probiotics daily• Vitamin D, and Vitamin C• Report changes in your stool to your PCP• Report any obvious blood in your stool to your PCP• Double probiotics whenever you need to take a course of antibiotics.

Categories
Skin Cancer

Skin Cancer Can Be Scary – Check Your Skin [Video]

Happy Halloween! It’s the season of pumpkins, phantoms, and all things spooky. But skin cancer doesn’t need to be one of the scares of the season. Check your skin at least once a month, in addition to your regular check-ins with your doctor. °°°Dr. James Goydos, MD, FACS has 20+ years experience as a Professor, Surgeon, Clinical Trial Leader, and Researcher in the area of skin cancer and genomics. Goydos has an MD from Rutgers Robert Wood Johnson Medical School, and has helped to save countless lives and transform cancer treatment at the Cancer Institute of New Jersey (CINJ) and UMDNJ. 🌐 FOLLOW https://jamesgoydos.comDr. James Goydos on “The Good Men Project” https://bit.ly/3kSnDdaJames Goydos Skin Cancer Research https://bit.ly/2Sa1tZM 📱SOCIAL https://www.facebook.com/jamesgoydosmdhttps://www.instagram.com/jamesgoydosmd/https://www.linkedin.com/in/jamesgoydos/ https://twitter.com/jamesgoydosmd ✍️ WRITING https://jamesgoydos.com/bloghttps://jamesgoydosmd.medium.comhttps://bit.ly/3vUblp1 Dr. James Goydos @ Medika Life https://refind.com/James-goydoshttps://bit.ly/3plO5hb Dr. James Goydos @ ManyStorieshttps://bit.ly/3z2mJkC Dr. James Goydos @ PenNamehttps://bit.ly/3yWK7jH Dr. James Goydos @ Smedianhttps://muckrack.com/james-goydos-md https://reedsy.com/author/james-goydos 🔬RESEARCH https://bit.ly/3zTEzq7 James Goydos on ORCIDhttps://bit.ly/3psOEpB Dr. James Goydos Skin Cancer research with Rutgershttps://bit.ly/3oxK5ID James Goydos Google Scholarhttps://bit.ly/3ciD6zO Dr. James Goydos Academia https://bit.ly/3yWKOJP James Goydos Semantic Scholarhttps://bit.ly/2YqnmTY James Goydos Loop Frontiershttps://bit.ly/3fSydQe James Goydos Publonshttps://bit.ly/34UG4Gx Dr. James Goydos Doximity🤓 DATA https://github.com/james-goydoshttps://www.kaggle.com/jamesgoydos🔀 MISC. https://bit.ly/2TwVzSH Dr. James Goydos Crunchbasehttps://www.pinterest.com/jamesgoydos/https://flipboard.com/@jamesgoydoshttps://www.tumblr.com/blog/james-goydoshttps://about.me/james-goydoshttps://bit.ly/3iflzfF James Goydos Quorahttps://www.reddit.com/user/James-Goydoshttps://vimeo.com/jamesgoydosmdhttps://www.behance.net/jamesgoydosmdhttps://bit.ly/3fN2M9X Dr. James Goydos Scribd https://www.slideshare.net/GoydosJameses Goydos, MD, FACS has 20+ years experience as a Professor, Surgeon, Clinical Trial Leader, and Researcher in the area of skin cancer and genomics. Goydos has an MD from Rutgers Robert Wood Johnson Medical School, and has helped to save countless lives and transform cancer treatment at the Cancer Institute of New Jersey (CINJ) and UMDNJ. 🌐 FOLLOW https://jamesgoydos.comDr. James Goydos on “The Good Men Project” https://bit.ly/3kSnDdaJames Goydos Skin Cancer Research https://bit.ly/2Sa1tZM 📱SOCIAL https://www.facebook.com/jamesgoydosmdhttps://www.instagram.com/jamesgoydosmd/https://www.linkedin.com/in/jamesgoydos/ https://twitter.com/jamesgoydosmd ✍️ WRITING https://jamesgoydos.com/bloghttps://jamesgoydosmd.medium.comhttps://bit.ly/3vUblp1 Dr. James Goydos @ Medika Life https://refind.com/James-goydoshttps://bit.ly/3plO5hb Dr. James Goydos @ ManyStorieshttps://bit.ly/3z2mJkC Dr. James Goydos @ PenNamehttps://bit.ly/3yWK7jH Dr. James Goydos @ Smedianhttps://muckrack.com/james-goydos-md https://reedsy.com/author/james-goydos 🔬RESEARCH https://bit.ly/3zTEzq7 James Goydos on ORCIDhttps://bit.ly/3psOEpB Dr. James Goydos Skin Cancer research with Rutgershttps://bit.ly/3oxK5ID James Goydos Google Scholarhttps://bit.ly/3ciD6zO Dr. James Goydos Academia https://bit.ly/3yWKOJP James Goydos Semantic Scholarhttps://bit.ly/2YqnmTY James Goydos Loop Frontiershttps://bit.ly/3fSydQe James Goydos Publonshttps://bit.ly/34UG4Gx Dr. James Goydos Doximity🤓 DATA https://github.com/james-goydoshttps://www.kaggle.com/jamesgoydos🔀 MISC. https://bit.ly/2TwVzSH Dr. James Goydos Crunchbasehttps://www.pinterest.com/jamesgoydos/https://flipboard.com/@jamesgoydoshttps://www.tumblr.com/blog/james-goydoshttps://about.me/james-goydoshttps://bit.ly/3iflzfF James Goydos Quorahttps://www.reddit.com/user/James-Goydoshttps://vimeo.com/jamesgoydosmdhttps://www.behance.net/jamesgoydosmdhttps://bit.ly/3fN2M9X Dr. James Goydos Scribd https://www.slideshare.net/GoydosJames