Cathie Wood (ARC Invest) sold all its $350 million holdings in Illumina Stock last year. Grail introduced a blood test that detects seven kinds of cancer. Illumina owns Grail.:) = TradingViews: https://www.tradingview.com/?offer_id=10&aff_id=25953Watch to get an understand of what is about to happen in the stock market:5 movies that explain what caused the 2009 financial crisis, and what happened after:The Big Short (2015)Margin Call (2011)Too Big to Fail (2011)99 Homes (2014)Inside Job (2010)Read these books to build your knowledge on how the markets work and what the future is going to look like.RECOMMENDED BOOKS (Affiliate Links)1. The Accidental Super Power by Peter Zeihan: https://amzn.to/3dEl9tL2. The Big Nine by Amy Webb: https://amzn.to/2yOJmPe3. The Code Breaker, Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson. https://amzn.to/2WNi6wf4. Digital Transformation, Survive and Thrive in an Era of Mass Extinction by Thomas M Siebel: https://amzn.to/3bqSjvx5. The Future is Faster Than You Think By Peter Diamandis and Steven Kotler https://amzn.to/2LnHu2K6. The Age of A.I. And our Human Future . By Henry Kissinger, Eric Schmidt, Daniel Huttenlocher https://amzn.to/3ylTx8eLink to our Discord: https://discord.io/bestofusThe Power of a Tribe: https://www.amazon.com/dp/B096TWBDM3/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1623414076&sr=8-1Get Surfshark VPN at https://surfshark.deals/INVESTORS and enter promo code INVESTORS for 83% off and 3 extra months for free! Help Kerry and Nita win the race against Childhood Cancer and keep their daughter Shay’s memory alive. Your support makes a direct impact in the fight against Pediatric Cancer at Children’s of Alabama by helping advance research in finding a cure for cancer. http://give.childrensal.org/bestofusRECOMMENDED VIDEO EQUIPMENT1. Canon EOS M6 Mark II Camera: https://amzn.to/2GJGE132. Rode VideoMic Pro+ Compact Directional On-Camera Shotgun Condenser Microphone https://amzn.to/32g9PRG3. Victiv 72-inch Camera Tripod Aluminum Monopod T72 Max. Height 182 cm – Lightweight and Compact for Travel with 3-way Swivel Head and 2 Quick Release Plates for Canon Nikon DSLR Video Shooting – Black https://amzn.to/2DMRemU4. UBeesize Tripod S, Premium Phone Tripod, Flexible Tripod with Wireless Remote Shutter, Compatible with iPhone/Android Samsung, Mini Tripod Stand Holder for Camera GoPro/Mobile Cell Phone (Upgraded) https://amzn.to/2RaCy4eThe Anti-Aging Supplement that I take: 4 Pack NMN Capsules with Maximum Strength- 500mg- High Absorption Nicotinamide Mononucleotide Supplement- Supports Brain Function & Anti Agingby NMN MAX https://amzn.to/3aG4QNeLearned about NMN in the book Lifespan by David Sinclair, https://amzn.to/3qVPPhXFITBIT Versa 3 Health and Fitness Smartwatch:https://www.amazon.com/gp/product/B08DFPV5Y2/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=B08DFPV5Y2&linkCode=as2&tag=bestofushomes-20&linkId=14033c1ca7e70a49f26987cac2b3d2b1RECOMMENDED BOOKS (Affiliate Links)1. The Accidental Super Power by Peter Zeihan: https://amzn.to/3dEl9tL2. The Big Nine by Amy Webb: https://amzn.to/2yOJmPe3. Supercharge Your Real Estate Sales by Kerry: https://amzn.to/2WqsUh94. The Code Breaker, Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson. https://amzn.to/2WNi6wf5. Digital Transformation, Survive and Thrive in an Era of Mass Extinction by Thomas M Siebel: https://amzn.to/3bqSjvx6. The Future is Faster Than You Think By Peter Diamandis and Steven Kotler https://amzn.to/2LnHu2K7. FIND HAPPINESS BY DISCOVERING Who YOU ARE AND Why YOU ARE YOU by Kerry Grinkmeyer https://amzn.to/2WphaLS8. A Crack in Creation, by Jennifer Doudna and Samuel Sternberg https://amzn.to/3qN2JhI9. The Industries of The Future, by Alec Ross: https://amzn.to/30eP3QB10. Bitcoin The Hard Money You Don’t Want to F*ck With. https://amzn.to/3xzU6cXhttps://store.wsj.com/shop/us/us/wsjuelnsb20/?11. The Long Game, China’s Grand Strategy to Displace American Order by Rush Doshi. https://amzn.to/2YAyLEDSubscribe to the Wall Street Journal:trackingCode=aaqwghw7&cid=WSJ_AFF_NA_ACQ_NA&n2IKsaD9=n2IKsaD9&Pg9aWOPT=Pg9aWOPT&Cp5dKJWb=Cp5dKJWb&APCc9OU1=APCc9OU1BestofUsInvestors MERCHANDISE:https://www.BestofUsInvestors.com/shopBest of Us Investors Tools:TubeBuddy: https://www.tubebuddy.com/BestofUsInvestors
In this session we present the most exciting results from our recent research efforts on Covid-19, cancer and rare diseases.
Rafael Fonseca, MD, Mayo Clinic, Phoenix, AZ, discusses the findings of a study investigating optimal treatment sequencing in multiple myeloma. With the available options for treatment expanding rapidly, determining the best strategies for upfront treatment and subsequent lines of therapy is of critical importance. In this analysis, the clinical value of daratumumab (DARA) first line compared to later lines was examined in patients with newly diagnosed transplant-ineligible multiple myeloma, since it is unclear where it performs optimally. It was shown that using DARA, lenalidomide, and dexamethasone (D-Rd) first line substantially improved overall survival compared with delaying DARA-based treatment until second line. Due to higher attrition rates in second line and beyond, the results demonstrate that achieving the longest possible progression-free survival in first line is key to optimize overall survival outcomes and therefore, saving DARA to later lines is a suboptimal approach. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.
Models, Inference and AlgorithmsBroad Institute of MIT and HarvardNovember 10, 2021Meeting: Biologically informed deep neural network for prostate cancer discoveryHaitham Elmarakeby (43:58-1:28:20)Van Allen Lab, Dana-Farber Cancer Institute; Broad InstituteDespite advances in prostate cancer treatment, including androgen deprivation therapy, metastatic castration resistant prostate cancer (mCRPC) remains largely incurable. Recent advances in collecting and sharing large quantities of genomic records from patients with primary and metastatic prostate cancer have not yet been matched with advances in computational model development to shed light on the underlying biology of mCRPC. Here we developed a biologically informed deep learning model (P-NET) that can accurately identify advanced prostate cancer samples based on their genomic profiles. By using a sparse model architecture that encodes different biological entities including genes, pathways, and biological processes, we were able to interpret the model in a way that is not matched by typical deep learning models. In a systematic unbiased way, P-NET recovered known biology of mCRPC via AR, TP53, RB1, and PTEN disruption, as well as less expected genes such as MDM4. We showed experimentally that MDM4 mediates enzalutamide resistance, showing that it may be a potential therapeutic target. We envision that our model will be helpful in both predicting clinical outcomes of cancer patients and generating biological hypotheses to better understand the underlying cancer biology.Primer: Genomic tools for interpreting patterns of somatic driver and passenger mutations in cancerFelix Dietlein (00:00-43:57)Van Allen Lab, Dana-Farber Cancer Institute; Broad InstituteMost cancer genomes contain a large number of mutations. Most of them are passenger mutations without direct effects on tumor signaling. A few of them are driver mutations that change the function of proteins in tumor cells and allow them to proliferate at a faster rate than normal tissue. Thus, the better we understand the processes that shape mutations in cancer genomes, the more precisely we can tailor therapies to a patient’s individual genome. However, passenger mutations cannot be clearly distinguished from driver mutations based on an individual tumor genome. Hence, genomic sequencing data from thousands of tumor patients have been generated, such as TCGA, for a detailed characterization of the landscape of driver mutations. While the most common driver events are well understood, large datasets and advanced computational tools are required to detect rare driver events. In this talk, I will give an overview of a tool for interpreting driver mutations I have worked on. I will explain the necessity of understanding passenger mutations and mutation distribution patterns, in general, to arrive at a clearer understanding of driver mutations.https://www.broadinstitute.org/talks/fall-2021/miaFor more information visit: https://www.broadinstitute.orgCopyright Broad Institute, 2021. All rights reserved.
Medical and Population Genetics PrimerBroad InstituteDebra Van EgerenThe Primer on Medical and Population Genetics is a series of informal weekly discussions of basic genetics topics that relate to human populations and disease. Experts from across the Broad Institute community give in-depth introductions to the basic principles of complex trait genetics, including human genetic variation, genotyping, DNA sequencing methods, statistics, data analysis, and more.Videos of these sessions are made freely available for viewing here and are geared toward a wide audience that includes research technicians, graduate students, postdoctoral fellows, and established investigators just entering the field.For more information, please visit:-Program in Medical Population Genetics (http://www.broadinstitute.org/node/224/)-Primer videos (http://www.broadinstitute.org/node/1339/)For more information visit: https://www.broadinstitute.orgCopyright Broad Institute, 2021. All rights reserved.