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Pediatric Cancer

TWiPO #90: Newborn Screening For Predisposition to Pediatric Cancers with Dr. Lisa Diller [Video]

TWiPO #90: Newborn Screening For Predisposition to Pediatric Cancers with Dr. Lisa Diller

This Week in Pediatric Oncology #90 – November 4, 2021

Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Lisa Diller from Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. Dr. Diller discusses the possibilities of genetic testing for pediatric cancer predisposition syndromes in newborn screening programs, but with uncertain benefits and costs. She recently authored a paper exploring mathematical modeling of a screening program for cost and benefit.

You can read her full paper here: https://pubmed.ncbi.nlm.nih.gov/33767345/

EXCERPT: We developed a simulation model to evaluate universal screening for a CPS panel. Cohorts of US newborns were simulated under universal screening versus usual care. Using data from clinical studies, ClinVar, and gnomAD, the presence of pathogenic/likely pathogenic (P/LP) variants in RET, RB1, TP53, DICER1, SUFU, PTCH1, SMARCB1, WT1, APC, ALK, and PHOX2B were assigned at birth. Newborns with identified variants underwent guideline surveillance. Survival benefit was modeled via reductions in advanced disease, cancer deaths, and treatment-related late mortality, assuming 100% adherence.

Have any thoughts? Questions? Ideas for future topics? Email us at TWIPO@solvingkidscancer.org. Subscribe to TWIPO to get notifications of new uploads.

Want to listen to TWIPO’s past episodes? Visit www.solvingkidscancer.org/podcast

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Pediatric Cancer

Austin Ekeler tells Dawson Knox he's hit the COVID list | Ekeler’s Edge [Video]

Los Angeles Chargers running back Austin Ekeler and Yahoo Sports’ Fantasy Expert Liz Loza check in on how Austin is feeling after hitting the COVID list. They also recap the Chargers' loss to the Chiefs and Donald Parham's injury. Liz and Austin rate the top waiver wire additions for Week 16 in a holiday themed game of Naughty or Nice. And Buffalo Bills TE Dawson Knox joins the show to talk about his fantasy team name, the Bills up and down season, and his gnarly hand after surgery. Dawson Knox launched an initiative called Knox Sox this season in partnership with For Bare Feet to raise money for P.U.N.T Pediatric Cancer Collaboration.#EkelersEdge #Chargers #DawsonKnoxThanks for watching! Subscribe to the Yahoo Sports channel here http://bit.ly/YSportsYTFollow us everywhere!Our Site http://www.yahoosports.comInstagram http://www.instagram.com/yahoosports Twitter http://www.twitter.com/yahoosports Facebook http://www.facebook.com/yahoosports Twitch https://www.twitch.tv/yahoosports

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Pediatric Cancer

Alternative method to animal testing for developing therapies against childhood cancer [Video]

Congratulations to St. Anna Children’s Cancer Research Institute (St. Anna CCRI) scientists Univ. Prof. Dr. Heinrich Kovar and Dr. Branka Radic-Sarikas for winning a grant from the Austrian Science Fund (FWF) under the program “Alternative methods to animal testing”. By using state-of-the-art technologies like single cell and spatial transcriptomics, organoids and 3D-bioprinting, the research project MetLung aims at creating and validating patient-specific 3D-models of lung metastatic solid tumors, ultimately guiding personalized drug selection. Metastasis is a major cause of death for children and adolescents with cancer, and the most common location of pediatric solid tumor metastases is the lung. “Our failure to cure patients with metastasis is partly due to a lack of understanding of tumor and niche cell interactions, and the associated mechanisms of treatment resistance. Knowledge about mediators of metastasis common to different tumor types may unravel novel therapeutic targets”, explains Branka Radic-Sarikas. “In this project we develop innovative in vitro models recapitulating the full complexity of lung metastases to test novel treatments. This approach will allow us to prioritize the most promising compounds for clinical development thus significantly reducing the need for pre-clinical testing in animals”, concludes Heinrich Kovar. Learn more: https://bit.ly/3FlJZwUFoto/Video Caption: Prof. Heinrich Kovar and Dr. Branka Radic-Sarikas explain how they intend to explore lung metastases in pediatric cancer through single cell analysis and 3D-modeling

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Pediatric Cancer

blood for the blood god - a technoblade anthem (ft. my discord community) [Video]

After two months and an old MacBook model constantly going through system overloads, here's the last community collaboration for this year, in honor of our favorite Orphan Obliterator, Anarchy Aficionado, Porcine Prince, Monarch of Malice, Death Incarnate: @Technoblade.Stream on your favorite platforms: https://distrokid.com/hyperfollow/preciousjewelamor1/blood-for-the-blood-godEarnings will be monitored closely and every cent earned will be donated to St. Jude Children's Research Hospital – a foundation aiding pediatric cancer patients not only in the US, but all around the world.Check out its global program here: https://www.stjude.org/globalCreditsArtGiulia Arthttps://www.youtube.com/channel/UCFeVMGcdK-rzE0fsq2CEBrAhttps://twitter.com/_giulia_artProductionPrecious Jewel AmorSoloistsSekiya Tsushima (https://twitter.com/SekiyaTsushima)Wassup_MKJ (https://www.youtube.com/channel/UCyJL7xNXRbNnxTj3pTXl4Yg)River_KingK (https://www.twitch.tv/river_kingk)Precious Jewel AmorLyricsWassup_mkj (same link as above)River_KingK (same link as above)@Fenyx AdeliaPotatchloride (https://www.youtube.com/channel/UCmxFwkw394cmfNOqhmIH6vw)StukiStarLittleAmber Sekiya Tsushima (same link as above)straightjacket_kickboxerArbee Lee (https://www.youtube.com/channel/UC14ridZO_Wc3q4ScUVRngAg)Drizvy (https://www.twitch.tv/drizvy)Precious Jewel AmorChoirAmary Ameliethyst (https://www.twitch.tv/ameliethystplays)Amity (https://www.youtube.com/channel/UCu7IGYRM-cACBNW0wDi-Fcw)Arbee Lee (same link as above)Archea AspenGraceK (https://www.youtube.com/channel/UC6EQCv6-juyh6hN0ZNobKlg)Ben/Benji @ButterscotchBread Calamamsi! (https://www.youtube.com/channel/UCi66OSNsWNXTU-4mSPkXRdg)Daikon (https://www.twitch.tv/daiikon_)desolate (https://twitter.com/DesolateStark)D1mitreuzz (https://linktr.ee/D1mitreuzz)Dracona (https://www.youtube.com/channel/UC073OFOX5q91aAs7x_P83Cw)Drizvy (same link as above)Ellaorwhatever (https://www.tiktok.com/@ellaorwhatever?)EllyBoost (https://twitter.com/EllyBoost)Elnuvahva (https://www.youtube.com/c/Elvaa)eVeeLFlam (https://www.instagram.com/lord_of_flamingoos/)ghostcat (https://twitter.com/ghostcat655)GPStarlight (https://www.youtube.com/channel/UCfR9dpsV_U01s4HmyKRmcPg)HydraStrom (https://twitter.com/HydraStrom1)Lilybap (https://www.twitch.tv/lilybap)Loomsqxi (https://www.youtube.com/channel/UCO9k0PlysePPYJWCQUNVfLw)Lynnjade (https://www.youtube.com/channel/UCvBFLn6BDfv-NirCaKXxORQ)MG (https://www.twitch.tv/RobinYourHouse_)MusicIsLife (https://www.twitch.tv/fionaendelmusic/)NeoX (https://www.instagram.com/neo_doarts/)Potatchloride (same link as above)RainbowFanAnne (https://www.twitch.tv/rainbowfananne)Rapsquack ShadoeDarkus shei (https://www.twitch.tv/sheiinanutshell)shlimeyy (https://open.spotify.com/artist/42G3RwNK2Jlu2I5QprSJ4s)SpaceIDragon StukiStar (https://twitter.com/StukiStar_)Summer (https://www.youtube.com/channel/UCr6hDxEsYdBmXPkvZcIqv1A)Toby TrinityTheAffinity (https://trinitytheaffinity.carrd.co/)TS Hellion VinyL (https://www.youtube.com/channel/UCYwqJAaKbCz-HJKEtwsOS7g)Zen_Da_Crazyyyyy Check out my Discord community! Pretty chill, lots of Pog people in there :D https://discord.gg/Qb3BzkmT94For more crap-posting, follow me on Twitter:https://twitter.com/pjewelamorI stream here:https://www.twitch.tv/preciousjewelamorFollow me on UltimateGuitar for the chords!https://www.ultimate-guitar.com/u/pjewelamorCheck out my carrd for additional links, including Spotify!https://preciousjewelamor.carrd.coSupport me by buying me a coffee!https://ko-fi.com/kofi4juju#technoblade #technothepig