Colon Cancer

Colorectal cancer

Presented By: Adam Burrack, M.S., Ph.D.Speaker Biography: Dr. Burrack obtained B.S. in Biology at the University of Wisconsin and a M.S. in Physiology at the University of Wisconsin-La Crosse. He went on to complete his PhD in Immunology at the University of Colorado – Anschutz Medical Campus. Family history of both type 1 diabetes and pancreatic cancer have greatly influenced Dr. Burrack’s scientific interests and research experiences. During graduate school, Dr. Burrack studied autoimmune diabetes recurrence and transplant recognition in a mouse model of type 1 diabetes in the laboratory of Ronald Gill. He then pursued post-doctoral at the University of Minnesota where he defined antigens that are recognized by alloreactive T cells direct transplant recognition. Webinar: Interrogating mechanisms of tumor-specific T cell exhaustion and activity in pancreatic ductal adenocarcinomaWebinar Abstract: Progress developing immune-based treatments to treat the highly lethal pancreatic ductal adenocarcinoma (PDA) has lagged behind other cancer types. This may be due, in part, to a fibroinflammatory and immunosuppressive tumor microenvironment (TME). To investigate mechanisms of resistance, we developed a novel mouse model to track pancreatic-tumor specific T cells. While expression of the bioluminescent molecule click beetle red (CB) by tumor epithelial cells permits longitudinal imaging of pancreatic tumor growth in vivo, CB also and unexpectedly generates an immunodominant CD8 T cell epitope (CB101-109:H-2Db) in C57Bl/6 mice. Orthotopic implantation of CB+ PDA cells into syngeneic immunocompetent mice results in the activation, expansion and intratumoral accumulation of CB-specific T cells, thereby modeling the large fraction of PDA cases that have a significant T cell infiltrate.Earn PACE Credits:1. Make sure you’re a registered member of LabRoots https://www.labroots.com/virtual-event/immuno-oncology-2021/agenda2. Watch the webinar on YouTube or on the LabRoots Website https://www.labroots.com/webinar/interrogating-mechanisms-tumor-specific-cell-exhaustion-activity-pancreatic-ductal-adenocarcinoma3. Click Here to get your PACE credits (Expiration date – June 02, 2023): https://www.labroots.com/credit/pace-credits/5808/third-partyLabRoots on Social:Facebook: https://www.facebook.com/LabRootsIncTwitter: https://twitter.com/LabRootsLinkedIn: https://www.linkedin.com/company/labrootsInstagram: https://www.instagram.com/labrootsincPinterest: https://www.pinterest.com/labroots/SnapChat: labroots_inc