Gut microbiome and treatment outcomes in HR+/HER2- breast cancer [Video]

Alexis Ann LeVee, MD, City of Hope, Duarte, CA, comments on the utility of stool microbial profiling in a Phase I/II study (NCT02778685), which assessed palbociclib, pembrolizumab, and endocrine therapy (ET) in patients with HR+/HER2- metastatic breast cancer (MBC). Gut microbiome profiling suggests specific bacterial taxa and metabolic pathways are associated with treatment response, indicating a potential biomarker for immune checkpoint inhibitor efficacy. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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