Charles Swanton, Francis Crick Institute in London, discusses his research on the initiation and progression of lung cancer in response to air pollution exposure. Focusing on non-small cell lung cancer (NSCLC) in never smokers, Prof. Swanton presents findings from mouse models and human epidemiology datasets, revealing a link between air pollution and increased tumor formation. He proposes that air pollutants trigger an inflammatory response mediated by macrophages, leading to the transformation of preexisting lung stem cells into tumors. Prof. Swanton explores the role of myeloid cells in cancer initiation and progression, highlighting the significance of clonal hematopoiesis of indeterminate potential (CHIP). This interview took place at the BTOG 2024 congress in Belfast, UK.
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