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Skin Cancer

The ‘RNA fishing’ reveals a new driver of malignancy and melanoma metastasis: Pdia6 constitutes a ne [Video]

Researchers have identified several proteins involved in the development of melanoma. One of the proteins – PDIA6 – was found very important to encourage malignancy. Experiments with mice show that melanoma cells with reduced levels of PDIA6 experience impaired ability to metastasize to the lungs. These findings can cause new therapeutic strategies that prevent the spread of melanoma from one part of the body to another.#RNAfishing #reveals #drivermelanoma #malignancymetastasisResearchers at the Center for Genomic Regulation have identified several proteins involved in the development of melanoma, the brightest form of skin cancer. One of the proteins – PDIA6 – was found very important to encourage malignancy. Experiments with mice show that melanoma cells with reduced levels of PDIA6 experience impaired ability to metastasize to the lungs. The researchers found that PDIA6 promoted melanoma malignancy by binding RNA molecules in tumor cells. Research authors, Journal of Nucleic Acids Research with the support of the “La Caixa” foundation identified the area on the surface of PDIA6 which binds to RNA molecules. With further research, this information can help design new therapy compounds that prevent the spread of melanoma from one part of the body to another. PDIA6 has previously been associated with the development of lymphoma, breast and lung cancer. If further research finds that PDIA6 also binds to RNA in other types of cancer, it can lead to therapeutic strategies that target the same action mechanisms in various tumors. This finding is possible thanks to the ‘RNA Fishing’ technique specifically designed to identify RNA binding proteins. This is a protein class that performs various biological functions, in cancer, provides resistance to cells by helping them adapt to changing environments and quickly respond to external threats, promoting cancer malignancy and resistance to therapy. This technique, also known as RNA Interactome Capture, involves fishing all RNA messenger in cells. The researchers then saw which protein attached to him, which informed the level and diversity of RNA binding activities that occur in the cell. “RNA binding protein is very interesting. Which protein might play an important role in the development of cancer, and conduct further experiments tell us how they work. We use this blueprint to uncover new vulnerability in melanoma, and we hope this can be repeated to find Target new therapy in other types of cancer as well, “explained Dr. Fátima Gebauer, a researcher at CRG and senior writer of this study. Of the hundreds of RNA binding proteins identified by this technique, researchers

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Skin Cancer

Update on Melanoma Skin Cancer & Opdivo Immunotherapy Treatments [Video]

I have Stage 3c melanoma skin cancer. I’ve had multiple surgeries, quarterly CT scans, needle biopsies and much more! This is an overview of everything I have gone through so far. I will have my 4th (of 12) treatment next week at Memorial Sloan Kettering. I am on Opdivo for 1 year. If you have any questions for you, leave it in the comments and I can get back to you. :-)—————————-Taken from Cancer.org August 2022 This explains exactly what I’ve been told by doctors and explains how it’s given to patients. Immunotherapy is the use of medicines to help a person’s own immune system recognize and destroy cancer cells more effectively. Several types of immunotherapy can be used to treat melanoma.Immune checkpoint inhibitors:An important part of the immune system is its ability to keep itself from attacking normal cells in the body. To do this, it uses “checkpoints,” which are proteins on immune cells that need to be turned on (or off) to start an immune response. Melanoma cells sometimes use these checkpoints to avoid being attacked by the immune system. But these drugs target the checkpoint proteins, helping to restore the immune response against melanoma cells.PD-1 inhibitors:Pembrolizumab (Keytruda) and nivolumab (Opdivo) are drugs that target PD-1, a protein on immune system cells called T cells that normally help keep these cells from attacking other cells in the body. By blocking PD-1, these drugs boost the immune response against melanoma cells. This can often shrink tumors and help people live longer.They can be used to treat melanomas:-That can’t be removed by surgery-That have spread to other parts of the body-After surgery (as adjuvant treatment) for certain stage II or III melanomas to try to lower the risk of the cancer coming backThese drugs are given as an intravenous (IV) infusion, typically every 2 to 6 weeks, depending on the drug and why it’s being given.

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Skin Cancer

Stage 4B Metastatic Melanoma Cancer Survivor, John Santoliquido shares his experience after 25 Years [Video]

Treated for metastatic melanoma stage 4B, John Santoliquido shares his journey at John Wayne Cancer Institute (now Saint John’s Cancer Institute) under the care of Dr. Richard Essner, Director of Surgical Oncology and Co-Director of Melanoma and Cutaneous Oncology Research Program, Dr. Steven O’day, Former Executive Director of the Saint John’s Cancer Institute and Cancer Clinic, and Dr. Kim Margolin, Medical Director of the Saint John’s Cancer Institute Melanoma Program. John participated in a clinical trial, tailoring his treatment to his needs. Learn more about the Center for Melanoma, Skin and Soft Tissue Tumors at https://www.saintjohnscancer.org/melanoma/Chapters:00:00 – Meet John Santoliquido03:08 – How would you describe your ongoing care with Dr. Richard Essner, Dr. Kim Margolin and the care team?#melanoma #stage4cancer #skincancerawareness #immunotherapy #sainjohnscancerinstitute

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Skin Cancer

Fall Asleep in Under 1 MINUTE | Body Mind Restoration | Major Melanoma Release | Deep Sleep [Video]

Here at The Peaceful Mind our aim is to provide sleep treatment to help you sleep better. For better sleep, reduce anxiety symptoms using sleeping & relaxing music. To help you sleep immediately with Rain Music, Rain Sounds, Rain sound, rain sound for sleeping, storm sound, heavy storm sound ,river sound, waterfall sound which are all natural sound for sleeping. Stress Relief Music, Sleep Music, Meditation Music, Study, Calming Music, Relaxing Sleep Music, Relax Music, Water sound, Waterfall sounds, Relaxing River sounds, River noise, natural sound, 30 minutes sleep music, 30 minute nap music, sleep in 30 minutes – you can use it for healing your self through meditation whilst listening to our soft music collection.This collection can also by used for treating of insomnia and anxiety. You can use our collection for insomnia treatment, sleeplessness, when you have difficulty sleeping. The sound of heavy storm is pretty effective way to reduce sleeplessness.You can use it as yoga music, as massage music or even as study music to provide focus. The soothing sounds of our relax music collection is multi purpose.A 30 minute power nap can make you feel fresh, more alert and focus. You can use our 30 minutes sleep music as meditation music as well.Sleeplessness or insomnia can be cured with relaxing music or to the sound of rain falling. And the river sound, rain sound or rain noise has very calming effect on nerves and lead to a peaceful mind. The rain sound effect is known to be of healing quality.The river sound, waterfall sounds and rain sound all helps you to relax, calms the nerves and create a peaceful mind. The relaxing river sound or river noise is the natural sleep music for deep sleep. You can sleep deep with water sound, rain sound or waterfall sounds as they relaxes your nerves and create a calming effect which helps with if you are having problem with not enough deep sleep. Water sounds for sleep are also known as calming music for nerves. The running water sound and calm water sound is known to reduce anxiety and calm nerves. It can also be used whilst as working music to help with concentration.You can listen to this deep sleep music whilst doing yoga to relax. This soothing music can be listened to just simply relax and promote healing meditation and Zen. It can be used as stress relief music as well as effective healing music or as work music. This calm music is perfect soft music which aids sleeping, meditation for anxiety and can be listened to as spa music whilst in spa.In our modern stressful world, sleeping is prerequisite for a healthy mind and body and practicing sleep meditation can be helped with this calm and soothing music as it aids deep sleep. This relaxing sleep music really helps. This music for sleeping fall sleep fast is one of the quickest way to fall asleep fast. How you use this music is your choice; as Zen music to relax after a long day, healing music if you are recovering from an illness, or a breakup, during stressful time this calming music will work as stress relief music. This is also music to fall asleep to and deep sleep helps you rejuvenate and crate positive energy.This is music to help you sleep as its calming music for sleep. It can help with your sleep frequency as you listen to this calm music you will relax and sleep better especially if you use is at bedtime music. If you wish to learn how to sleep fast and achieve deepest sleep stage then listen to this soft music which is also a soothing meditation music and you will feel relax and fall asleep fast.This relax music can help to promote inner peace through meditation, Zen meditation, mediation for anxiety and yoga. With its binaural beats this sleeping music can help release positive energy. Meditation music, relaxing music for stress has a calming affect on the mind.