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Blood Cancer

An overview of CAR-T therapy in DLBCL and MCL [Video]

Peter Riedell, MD, University of Chicago Medicine, Chicago, IL, comments on the key topics of a talk designed to provide oncologists and bone marrow transplant (BMT) specialists with an overview of CAR-T therapy in diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). The presentation recapitulated data on the three approved CAR-T products in DLBCL in the third-line setting, axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel), as well as data from the three pivotal trials comparing these CAR-T therapies to standard of care (SOC) in second line in DLBCL. Advances in MCL were also highlighted and included data showing the benefits of brexucabtagene autoleucel (brexu-cel) in these patients. This interview took place at the Transplantation & Cellular Therapy (TCT) Meetings of ASTCT™ and CIBMTR® 2022 in Salt Lake City, Utah.

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Blood Cancer

Updates in CAR-T for non-Hodgkin lymphoma [Video]

In this video, Graham Collins, MA, MBBS, MRCP, FRCPath, DPhil, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, summarizes the key updates in CAR-T therapy for the treatment of non-Hodgkin lymphoma. Dr Collins highlights three studies from the 2021 ASH conference that focus on CAR-T therapy in first relapse for B-cell lymphoma: ZUMA-7, BELINDA, and TRANSFORM (NCT03391466, NCT03570892, NCT03575351). In his discussion, Dr Collins discusses and compares the results and subtle differences in these studies, including primary endpoints and outcomes. Following this, Dr Collins focuses his interest on the ZUMA-12 study (NCT03761056), explaining the methodology and results. This interview took place at the 63rd ASH Annual Meeting and Exposition, Atlanta, 2021.

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Blood Cancer

Lymphoma highlights from ASH 2021 [Video]

Amitkumar Mehta, MD, UAB School of Medicine, Birmingham, AL, comments on his highlights in the field of lymphoma presented at ASH 2021, including the Phase III POLARIX trial (NCT03274492) of polatuzumab vedotin (R-CHP) in diffuse large B-cell lymphoma (DLBCL). Dr Mehta additionally talks on the ZUMA-7 (NCT03391466), TRANSFORM (NCT03575351), BELINDA (NCT03570892), and ELARA (NCT03568461) trials, which all assessed chimeric antigen receptor (CAR) T-cell therapies, as well as bispecific antibodies such as glofitamab and mosunetuzumab. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.

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Blood Cancer

Updates in CAR-T for non-Hodgkin lymphoma [Video]

In this video, Graham Collins, MA, MBBS, MRCP, FRCPath, DPhil, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, summarizes the key updates in CAR-T therapy for the treatment of non-Hodgkin lymphoma. Dr Collins highlights three studies from the 2021 ASH conference that focus on CAR-T therapy in first relapse for B-cell lymphoma: ZUMA-7, BELINDA, and TRANSFORM (NCT03391466, NCT03570892, NCT03575351). In his discussion, Dr Collins discusses and compares the results and subtle differences in these studies, including primary endpoints and outcomes. Following this, Dr Collins focuses his interest on the ZUMA-12 study (NCT03761056), explaining the methodology and results. This interview took place at the 63rd ASH Annual Meeting and Exposition, Atlanta, 2021.

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Blood Cancer

Second-line CAR-T therapy in B-cell lymphoma [Video]

Peter M. Riedell, MD, University of Chicago Medicine, Chicago, IL, shares updates from the Phase III ZUMA-7 trial (NCT03391466) of the anti CD19 axicabtagene ciloleucel (axi-cel), a chimeric antigen receptor (CAR) T-cell therapy in patients with relapsed/refractory (r/r) large B-cell lymphoma (LBCL). A superior event-free survival and overall survival were reported in the axi-cel arm and the findings corroborate with data from the Phase III TRANSFORM trial (NCT03575351), demonstrating the potential of CAR T-cell therapy as a second-line option for LBCL. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.

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Blood Cancer

The role of CAR-T therapy in hematologic malignancies [Video]

Michael Bishop, MD, University of Chicago, Chicago, IL, describes advances in chimeric antigen receptor (CAR) T-cell therapy for hematologic malignancies. Data from the JULIET (NCT02445248), TRANSFORM (NCT03575351), BELINDA (NCT03570892), ZUMA-1 (NCT02348216), and ZUMA-7 (NCT03391466) trials have demonstrated CAR T-cell therapy as a promising frontline therapy in non-Hodgkin lymphoma. Dr Bishop additionally highlights updates in multiple myeloma and acute lymphoblastic leukemia (ALL), as well as strategies to manage CAR T-cell toxicity. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.

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Blood Cancer

ZUMA-7: Axi-cel in r/r large B-cell lymphoma [Video]

Frederick Locke, MD, Moffitt Cancer Center, Tampa, FL, presents results from the Phase III ZUMA-7 trial (NCT03391466) which assessed axicabtagene ciloleucel (axi-cel), an autologous anti‑CD19 chimeric antigen receptor (CAR) T-cell therapy, in patients with relapsed/refractory (r/r) large B-cell lymphoma (LBCL). 359 patients either received axi-cel or the standard of care, with the primary endpoint being event-free survival (EFS). After a 24 month follow-up, patients in the axi-cel arm demonstrated a superior EFS and overall response rate (ORR). Overall survival (OS) was additionally superior in the axi-cel arm, but was not statistically significant. The results suggest axi-cel can be a second-line treatment for r/r LBCL. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.

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Blood Cancer

DLBCL updates at ASH 2021 [Video]

Chan Yoon Cheah, MBBS, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, provides key updates in the field of diffuse large B-cell lymphoma (DLBCL) that will be discussed at ASL 2021. He comments on the results from the Phase III ZUMA-7 trial (NCT03391466) which investigated axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, in patients with relapsed/refractory (r/r) DLBCL. Dr Cheah additionally highlights potential data from the Phase III POLARIX trial (NCT03274492), which compared polatuzumab vedotin, an antibody-drug conjugate, with R-CHP against R-CHOP. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.

Categories
Blood Cancer

Looking forward to ASH 2021: key updates in DLBCL [Video]

Graham Collins, MA, MBBS, MRCP, FRCPath, DPhil, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, gives an overview of the main updates in diffuse large B-cell lymphoma (DLBCL) that will be discussed at the upcoming ASH annual meeting. To begin with, the data from the POLARIX trial comparing the efficacy of polatuzumab vedotin plus R-CHP versus R-CHOP in previously untreated DLBCL (NCT03274492) is eagerly awaited, as a recent press release reported that the primary endpoint was met. In addition, updates from the ZUMA-7 study investigating the efficacy of axicabtagene ciloleucel versus standard of care (SOC) in relapsed/refractory DLBCL (NCT03391466) will be presented at ASH, as well as new exciting data on bispecific antibodies for lymphoma. Dr Collins is also looking forward to hearing more details about the real-world data from a study evaluating the outcomes of different central nervous system (CNS) prophylaxis strategies in DLBCL which could have a substantial impact on clinical practice. Finally, an interesting study investigating the use of cell-free DNA (cfDNA) as a diagnostic and prognostic biomarker in primary CNS lymphoma will be presented at the Plenary Scientific Session. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.