Antibiotic Resistance The Silent Pandemic [Video]

In this eye-opening video, we delve into the world of antibiotic resistance, a silent yet dangerous pandemic that continues to shape human history. Discover how the overuse and misuse of antibiotics has led to bacteria evolving the ability to evade our once-reliable medicines.

This video will cover the following topics:

– What are bacteria? What are antibiotics?
– Alexander Fleming’s discovery of antibiotics
– First case of antibiotic resistance?
– Different ways of acquiring resistance
– Antibiotic resistance mechanisms
– Factors contributing to resistance, and the consequences of antibiotic
– Global efforts/Future innovations

This video was made by McMaster University students Marie Balea, Wajiha Khan, and Aaron Taylor, in collaboration with the Demystifying Research McMaster Program.

This video is provided for general and educational information only. Please consult your health care provider for information about your health.

Copyright McMaster University 2024

#antibioticresistance #superbugs #globalhealth #bacteria #pathogens #antibiotics

References:
National Human Genome Research Institute. (n.d.). Bacteria. Genetics Home Reference. https://www.genome.gov/genetics-glossary/Bacteria

American Chemical Society. (n.d.). Alexander Fleming and the Discovery of Penicillin. http://www.acs.org/content/acs/en/education/whatischemistry/landmarks/flemingpenicillin.html

Tan, S. Y., & Tatsumura, Y. (2015). Alexander Fleming (1881-1955): Discoverer of penicillin. Singapore medical journal, 56(7), 366–367. https://doi.org/10.11622/smedj.2015105 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520913/

Lobanovska, M., & Pilla, G. (2017). Penicillin’s Discovery and Antibiotic Resistance: Lessons for the Future?. The Yale journal of biology and medicine, 90(1), 135–145. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369031/

World Health Organization. (2020, January 17). Lack of new antibiotics threatens global efforts to contain drug-resistant infections. https://www.who.int/news/item/17-01-2020-lack-of-new-antibiotics-threatens-global-efforts-to-contain-drug-resistant-infections#:~:text=Declining%20private%20investment%20and%20lack,weak%20pipeline%20for%20antibiotic%20agents

World Health Organization. (2021). Antibiotic Resistance. https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance#:~:text=Bacteria%2C%20not%20humans%20or%20animals,hospital%20stays%2C%20and%20increased%20mortality

World Health Organization. (2015, May). Global action plan on antimicrobial resistance. https://www.who.int/publications/i/item/9789241509763

Principi N, Silvestri E, Esposito S. (2019). A Review on Antibiotic Resistance: Alarm Bells are Ringing. Frontiers in Pharmacology, 10, 513. https://doi.org/10.3389/fphar.2019.00513

Chegini, Z., Khoshbayan, A., Taati Moghadam, M., Farahani, I., Jazireian, P., & Shariati, A. (2020). Bacteriophage therapy against Pseudomonas aeruginosa biofilms: a review. Annals of Clinical Microbiology and Antimicrobials, 19(1), 45. https://doi.org/10.1186/s12941-020-00389-5

Qin, S., Xiao, W., Zhou, C., Pu, Q., Deng, X., Lan, L., Liang, H., Song, X., & Wu, M. (2022). Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics. Signal Transduction and Targeted Therapy, 7(1), 199. https://doi.org/10.1038/s41392-022-01056-1