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Genetic and Germline Testing + Q&A | Brian Helfand, MD & Mark Moyad, MD, MPH [Video]

Prostate Cancer

Genetic and Germline Testing + Q&A | Brian Helfand, MD & Mark Moyad, MD, MPH #PCRI

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0:58 Genetics 101: Germline vs Somatic Mutations
5:04 Germline Genetic Assessment: It Takes Three
11:26 Single Nucleotide Polymorphisms (SNP’s) and Prostate Cancer
13:08 What is a Genetic Risk Score (GRS)?
15:21 A Genetic Risk Score is More Informative than Family History
17:07 Benefits of Genetic Assessment in Prostate Cancer
19:30 Four Different Benefits of Germline Genetic Testing
19:45 Statistical Evidence for Guideline-recommended Genes
22:40 Genetic Risk Score (GRS)
23:28 Utility of Genetic Risk Score
25:13 Access prognosis for localized prostate cancer patients
26:18 Monogenic Genes for Prostate Cancer Progression
27:24 Mutation Carriers and Prostate Cancer Progression
29:08 Genetic Risk Score and Active Surveillance
30:30 Genetic factors associated with prostate cancer conversion from AS to treatment
32:09 Recommends therapeutic responses for advanced prostate cancer patients
32:40 Monogenetic Genes for PARPi
35:16 Monogenetic Genes for Prostate Cancer Response to ADT
37:00 Summary
38:36 What is New in the Field of Germline Genetic Testing?
41:32 Risks of Complications Among All Men with Prostate Cancer
43:38 Comparison of CVD Risk: Metastatic PC vs Localized PC
45:33 Comparison of Osteoporosis Risk: Metastatic PC vs Localized PC
46:41 Comparison of Depression Risk: Metastatic PC vs Localized PC
47:30 Comparison of Genetic Risk of Depression Among Men with Metastatic PC
1:00:16 Two types of genetic testing – Germline and Somatic
1:01:57 BRCA 2 mutation found on Somatic test- does the family need to be tested?
1:05:40 BRCA 2 mutation found on Somatic test – should you get a germline test?
1:08:38 60% of patients who don’t meet insurance family history criteria will harbor a mutation
1:10:47 Most companies charge $249 or less for germline test
1:11:43 When would I know to get these tests?
1:15:50 Is a Polygenic Risk Score (PRS) recommended?
1:18:00 What critics are saying
1:20:33 Is PRS being used for Active Surveillance patients?
1:21:03 What does family history really mean?
1:26:53 Why aren’t all men on active surveillance tested for BRCA mutations?
1:35:46 NCCN Germline Testing Guidelines
1:37:57 Obstacles to Genetic Testing
1:42:12 Lynch Syndrome
1:48:51 Does a heart healthy lifestyle change genes and lower/eliminate lethal PCa risk?
1:53:45 Is the PRS test ready for primetime?
1:54:31 What does “Gene variation of unknown significance” mean?
1:56:58 What are the drawbacks of Over The Counter testing?
2:00:48 Liquid biopsy – what are the pitfalls?
2:04:20 Artificial Intelligence – what is it’s impact?
2:07:12 Final thoughts

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The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at or contact our free helpline with any questions that you have at Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.

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