Genomic differences between urachal and non-urachal bladder adenocarcinoma [Video]

Antonio Cigliola, MD, IRCCS San Raffaele Hospital, Milan, Italy, discusses findings from a study assessing genomic disparities between urachal and non-urachal bladder adenocarcinoma to identify potential therapeutic targets. Distinct genomic alterations were found, where colorectal cancer-associated mutations were more prevalent in urachal adenocarcinoma, while non-urachal adenocarcinoma exhibited mutations typical of urothelial carcinoma. Both types showed targetable mutations such as PIK3CA and ERBB2, and biomarkers for anti-PD(L)1 therapy were also infrequent. This interview took place at the ASCO GU Cancers Symposium 2024 in San Francisco, CA.

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