Impact of MRI and 12-gene expression assay on radiotherapy in DCIS: 5-year findings [Video]

Seema Khan, MD, Northwestern Feinberg School of Medicine, Chicago, IL, discusses findings from a prospective, single-arm, multicenter study examining the impact of magnetic resonance imaging (MRI) and a 12-gene expression assay on optimizing radiotherapy for ductal carcinoma in situ (DCIS). The study assessed ipsilateral breast events (IBE) at 5 years and reported similar rates in the low DCIS Score (DS) group treated with wide local excision (WLE) alone compared to the inter/hi DS group treated with WLE and radiation. This contradicts previous studies showing significant differences in IBE rates based on DS with excision alone. Prof. Khan suggests that omitting radiotherapy post-surgery may be suitable for DCIS patients with low DS, while patients with inter/hi DS may benefit from radiation. She acknowledges the study’s limitations, emphasizing the need for larger, randomized trials with diverse populations, particularly in age representation, to confirm these findings. This interview was conducted at the San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX.

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