Metastatic Prostate Cancer Cells Effect on Tumor Microenvironment-Jordan Beam [Video]

Co-Authors: Renee Ormsby, PhD, University of Oxford, Oxford U.K.; Young Eun Park, PhD, University of Oxford, Oxford U.K.; Claire Edwards, PhD University of Oxford, Oxford U.K.; Jessica Whitburn, PhD University of Oxford, Oxford U.K.; Majd Zayzafoon, M.D. PhD University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL

Introduction: Bone is the main site of prostate cancer (PCa) metastasis, with an increased mortality rate for PCa patients. PCa cells interact with osteoblasts (bone-forming cells) to colonize the bone microenvironment (including adipocytes). The exact interactions that occur between osteoblasts, adipocytes and PCa cells are poorly understood. To investigate this, PCa cells were cultured ± osteoblasts or conditioned media from adipocytes.

References: 1 Whitburn J, Rao SR, Morris EV, Tabata S, Hirayama A, Soga T, Edwards JR, Kaya Z, Palmer C, Hamdy FC, Edwards CM. Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival. Sci Adv. 2022 Feb 25;8(8):eabf9096. doi:
10.1126/sciadv.abf9096. Epub 2022 Feb 25. PMID: 35213227; PMCID:PMC8880772