Novel immunotherapy combinations for SCLC [Video]

Ticiana Leal, MD, Winship Cancer Institute, Atlanta, GA, discusses emerging immunotherapy combinations in small cell lung cancer (SCLC). The current standard of care for patients with extensive stage SCLC is a combination of chemotherapy and immunotherapy, however most patients still experience disease progression. The Phase II SWOG S1929 trial (NCT04334941) investigated atezolizumab and talazoparib, with SLFN11 as a predictive biomarker, while other studies targeted immunosuppressants. The Phase III ETER701 trial (NCT04234607), assessed anlotinib, a tyrosine kinase inhibitor (TKI) with TQB2450, a PD-L1 inhibitor, whereas the Phase II CeLEBrATE trial (NCT04730999), assessed bevacizumab and atezolizumab. Dr Leal also comments on the ongoing Phase I/II trial (NCT04702880) of BMS-986012 as well as epigenetic regulators in conjunction with biomarker studies. This interview took place at 2024 Targeted Therapies of Lung Cancer Meeting (TTLC 2024) in Santa Monica, CA.

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