S2303: nivolumab combo v paclitaxel + ramucirumab in PD-L1 CPS ≥ 1 gastric/esophageal adenocarcinoma [Video]

Anwaar Saeed, MD, University of Pittsburgh Medical Center, Pittsburgh, PA, discusses the rationale behind the Phase I/II PARAMMUNE trial (NCT06203600) (SWOG2303) investigating the efficacy and safety of nivolumab, paclitaxel, and ramucirumab compared to paclitaxel and ramucirumab in advanced stage MSS/pMMR PD-L1 CPS ≥ 1 gastric and esophageal adenocarcinoma. The trial is motivated by the promising results of the multi-center phase I/II trial that evaluated the addition of nivolumab to 2nd line ramucirumab plus paclitaxel. The study aims to explore the predictive impact of PD-L1 CPS and assess the primary endpoints of progression-free survival (PFS) in phase II and overall survival (OS) in Phase III. This interview took place at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.