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Pediatric Cancer

Scientist Stories: Crystal Mackall, Pioneer in Immune Cell Exhaustion and Cell Therapies [Video]

Crystal L Mackall MD is the Ernest and Amelia Gallo Family Professor of Pediatrics and Medicine at Stanford University, the Founding Director of the Stanford Center for Cancer Cell Therapy, Associate Director of the Stanford Cancer Institute, Leader of the Cancer Immunotherapy Program and Director of the Parker Institute for Cancer Immunotherapy @ Stanford. During a 27-year tenure at NCI culminating as Chief of the Pediatric Oncology Branch and Head of the Immunology Section and since 2016 at Stanford, she has led an internationally recognized translational research program focused on immune-oncology. Her work has advanced understanding of fundamental immunology and translated this understanding for the treatment of human disease with a major focus on children’s cancers. She has led numerous first-in-human and first-in-child clinical trials spanning dendritic cell vaccines, cytokines, and adoptive immunotherapy using NK cells and genetically modified T cells. Her work is credited with identifying an essential role for the thymus in human T cell regeneration (NEJM 1995) and discovering IL-7 as the master regulator of T cell homeostasis (Blood 2001, J Exp Med 2008). Her group was among the first to demonstrate impressive activity of CD19-CAR in pediatric leukemia (Lancet 2015), developed a CD22-CAR that is the only active salvage therapy for CAR19 resistant B cell malignancies (Nat Med 2018, J Clin Onc 2020, Blood 2021), demonstrated preclinical activity of GD2 targeting CARs for pediatric diffuse intrinsic pontine glioma (Nat Med 2018), demonstrated superiority of regional CNS delivery of CAR T cells for brain tumors (Nat Med 2020) and demonstrated impressive clinical activity of GD2-CAR T cells in this disease (NCT04196413), which is among the first to demonstrate significant and consistent activity of CAR T cells in solid cancers (Nature 2022). Her group identified T cell exhaustion as a major feature CAR T cell potency (Nat Med 2015), created the first exhaustion-resistance (Nature 2019) and exhaustion-reversal platforms (Science 2021) and developed a best-in-class regulatable “remote-controlled” CAR T cell platform (Cell, 2022). She serves in numerous national leadership positions, including Co-PI of a Pediatric Immunotherapy Discovery and Development Network U54 grant, and co-Leader of the St. Baldrick’s-StandUp2Cancer Pediatric Dream Team. She has received numerous awards, including election as a fellow of the AACR Academy, the Smalley Award for outstanding contributions to cancer immunotherapy from the Society for the Immunotherapy of Cancer, the AACR-St.Baldrick’s Distinguished Achievement Award for Pediatric Cancer Research, and the Nobility in Science Award from the Sarcoma Foundation of America. She has published over 250 manuscripts and her h-index in August 2022 according to google scholar is 96 and founded 3 biotech companies. Crystal is Board Certified in Pediatrics, Pediatric Hematology-Oncology and Internal Medicine.https://en.wikipedia.org/wiki/Crystal_Mackall#biotechnology #science #vc #startup #startups #startupideas #biology #biotech #chemistry #business #speech #speeches #investing #investment #lifescience #casestudy #scientist #scientists #inventors #inventor #inventions #invention #research #innovation #siliconvalley #entrepreneur #entrepreneurship #entrepreneurs #healthcare #genomics #genetics #history #biologia #technology #tech #founderstories #founder #founders #founderstory #scienceandtechnology #sciencestory #stories #bioengineering #engineering #engineer #biochemistry #discovery #discover #technical #health #education #educational #learning #learn #podcast #podcasts #podcasting #podcaster #technews Axial Newsletter: https://axial.substack.com/Build with Axial: https://axial22.axialvc.com/

Categories
Pediatric Cancer

Ep. 266 – Coffee With Khalipa | Pack A Big Punch [Video]

Skip the decaf today and get ready to pack some punch! Did you know that you can still get a good workout in with limited equipment? Yep – you don’t need the nicest garage gym in town to get super fit. It’s all about moving large loads, long distances, quickly. Take a listen for Jason’s favorite minimal equipment movement!Jason is the founder of NCFIT, a global fitness company with brick and mortar locations, corporate wellness, and digital services. He is a 3x Team USA CrossFit member and CrossFit Games Champion. A Pediatric Cancer Advocate after his daughter was diagnosed with Leukemia in 2016, host of the Effort Over Everything Podcast, and BJJ Purple Belt.Find Jason Here:IG: https://www.instagram.com/jasonkhalipa/Podcast: https://www.nc.fit/edit/podcasts/effort-over-everythingNCFIT Website: https://www.nc.fit/ NCFIT Collective: https://www.ncfitcollective.fit/Philanthropy: https://avaskitchen.org/

Categories
Pediatric Cancer

Ep. 265 – Jason & Gabe | The Clock Is Your Training Partner [Video]

The boys are back and Gabe FINALLY tried his first Jiu-Jitsu Class (Jason’s dream come true). Aside from BJJ, they go into baseball, classic fitness tests, and the 3 best supplements on the market. Kick back, turn up the volume, and listen to today’s episode of EOE.Follow JasonFollow GabeOn the NCFIT Edit: 3 Beneficial SupplementsFun, Effective Workouts: NCFIT AppWeekly Motivation: EOE NewsletterLevel Up Your Business: Build Better NewsletterSuit Up: NCFIT ShopGym Owners: NCFIT Collective ProgrammingVisit NCFIT OnlineJason is the founder of NCFIT, a global fitness company with brick and mortar locations, corporate wellness, and digital services. He is a 3x Team USA CrossFit member and CrossFit Games Champion. A Pediatric Cancer Advocate after his daughter was diagnosed with Leukemia in 2016, host of the Effort Over Everything Podcast, and BJJ Purple Belt.Find Jason Here:IG: https://www.instagram.com/jasonkhalipa/Podcast: https://www.nc.fit/edit/podcasts/effort-over-everythingNCFIT Website: https://www.nc.fit/ NCFIT Collective: https://www.ncfitcollective.fit/Philanthropy: https://avaskitchen.org/

Categories
Pediatric Cancer

UP-DOWN V. BURPEE W/ JASON KHALIPA [Video]

Jason is here to answer everyone’s favorite question: Up-Down or Burpee?Jason is the founder of NCFIT, a global fitness company with brick and mortar locations, corporate wellness, and digital services. He is a 3x Team USA CrossFit member and CrossFit Games Champion. A Pediatric Cancer Advocate after his daughter was diagnosed with Leukemia in 2016, host of the Effort Over Everything Podcast, and BJJ Purple Belt.Find Jason Here:IG: https://www.instagram.com/jasonkhalipa/Podcast: https://www.nc.fit/edit/podcasts/effort-over-everythingNCFIT Website: https://www.nc.fit/ NCFIT Collective: https://www.ncfitcollective.fit/Philanthropy: https://avaskitchen.org/

Categories
Pediatric Cancer

Ep. 264 – Coffee With Khalipa | Make Your Morning [Video]

Jason Khalipa is back at it with another cup of coffee and another episode! Do you have a morning routine? Listen to Jason explain how he starts off the day on the right foot and why making your morning is so important. Jason is the founder of NCFIT, a global fitness company with brick and mortar locations, corporate wellness, and digital services. He is a 3x Team USA CrossFit member and CrossFit Games Champion. A Pediatric Cancer Advocate after his daughter was diagnosed with Leukemia in 2016, host of the Effort Over Everything Podcast, and BJJ Purple Belt.Find Jason Here:IG: https://www.instagram.com/jasonkhalipa/Podcast: https://www.nc.fit/edit/podcasts/effort-over-everythingNCFIT Website: https://www.nc.fit/ NCFIT Collective: https://www.ncfitcollective.fit/Philanthropy: https://avaskitchen.org/

Categories
Pediatric Cancer

HOW TO GET YOUR FIRST BAR MUSCLE-UP [Video]

Jason is the founder of NCFIT, a global fitness company with brick and mortar locations, corporate wellness, and digital services. He is a 3x Team USA CrossFit member and CrossFit Games Champion. A Pediatric Cancer Advocate after his daughter was diagnosed with Leukemia in 2016, host of the Effort Over Everything Podcast, and BJJ Purple Belt.Find Jason Here:IG: https://www.instagram.com/jasonkhalipa/Podcast: https://www.nc.fit/edit/podcasts/effort-over-everythingNCFIT Website: https://www.nc.fit/ NCFIT Collective: https://www.ncfitcollective.fit/Philanthropy: https://avaskitchen.org/

Categories
Pediatric Cancer

Ep. 263 – Jason & Gabe | Jason Khalipa Energy [Video]

Jason & Gabe are back at it with another jam-packed episode of EOE! After recalling some of the craziest situations they’ve ever been in, they go into all things fitness. Whether you own a gym or you workout in one, this episode is for you. Enjoy!Jason is the founder of NCFIT, a global fitness company with brick and mortar locations, corporate wellness, and digital services. He is a 3x Team USA CrossFit member and CrossFit Games Champion. A Pediatric Cancer Advocate after his daughter was diagnosed with Leukemia in 2016, host of the Effort Over Everything Podcast, and BJJ Purple Belt.Find Jason Here:IG: https://www.instagram.com/jasonkhalipa/Podcast: https://www.nc.fit/edit/podcasts/effort-over-everythingNCFIT Website: https://www.nc.fit/ NCFIT Collective: https://www.ncfitcollective.fit/Philanthropy: https://avaskitchen.org/

Categories
Pediatric Cancer

Ep. 262 – Alain Ngalani | Win or Lose, Kick the Other Guy in the Face [Video]

In this episode, Jason talks to five-time World Champion Alain Ngalani. At a young age, Alain’s mother taught him to stand up for himself through self-defense. Martial Arts has become his passion and way of life since then and he’s gone on to earn black belts in four different disciplines along the way. Listen to today’s episode to hear Jason and Alain talk more about following your instincts, staying humble, and never losing a fight without kicking the other guy in the face.Jason is the founder of NCFIT, a global fitness company with brick and mortar locations, corporate wellness, and digital services. He is a 3x Team USA CrossFit member and CrossFit Games Champion. A Pediatric Cancer Advocate after his daughter was diagnosed with Leukemia in 2016, host of the Effort Over Everything Podcast, and BJJ Purple Belt.Find Jason Here:IG: https://www.instagram.com/jasonkhalipa/Podcast: https://www.nc.fit/edit/podcasts/effort-over-everythingNCFIT Website: https://www.nc.fit/ NCFIT Collective: https://www.ncfitcollective.fit/Philanthropy: https://avaskitchen.org/

Categories
Pediatric Cancer

Meet 2022 ‘Frank the Tank’ Scholar Liliana Paez Gallardo! [Video]

Meet our 2022 ‘Frank the Tank’ Scholar: Liliana Paez Gallardo!!! Liliana is a leukemia survivor and social work graduate student at Cal State Fullerton, with plans of one day serving pediatric cancer patients.”With this scholarship, I for sure can go to grad school now, and my dreams are coming true, so thank you SO much.” –Liliana Paez Gallardo, 2022 Frank the Tank ScholarWe are delighted to welcome Liliana into the Cancer for College family and help her accomplish her dream of giving back, just like Frank Lozoya did. To support other cancer survivors like Liliana, visit https://www.classy.org/campaign/frank-the-tank-scholarship/c157393 today!#destinedtomakeadifference #cfcfamily #cancer #cancersurvivors #cancersurvivor #cancerwarriors #cancerawareness #cancersucks #cancercommunity #leukemia #leukemiasurvivor #highereducation #college #futuredoctor #inspiration #inspiring #socialwork #futuresocialworker #givingback #teamfrankthetank #frankthetank

Categories
Pediatric Cancer

CAR T-Cell Therapy: The Patient Perspective [Video]

Carlos Sandi, father of a childhood cancer survivor who received CAR T-cell therapy treatment at the NIH Clinical Center, shares the family’s journey and their experience with CAR T-cell therapy during the May 2020 virtual conference, “CAR T-Cell Therapy: Beyond the Storm” hosted by the NCI Center for Cancer Research.