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Pediatric Cancer

Scientist Stories: Crystal Mackall, Pioneer in Immune Cell Exhaustion and Cell Therapies [Video]

Crystal L Mackall MD is the Ernest and Amelia Gallo Family Professor of Pediatrics and Medicine at Stanford University, the Founding Director of the Stanford Center for Cancer Cell Therapy, Associate Director of the Stanford Cancer Institute, Leader of the Cancer Immunotherapy Program and Director of the Parker Institute for Cancer Immunotherapy @ Stanford. During a 27-year tenure at NCI culminating as Chief of the Pediatric Oncology Branch and Head of the Immunology Section and since 2016 at Stanford, she has led an internationally recognized translational research program focused on immune-oncology. Her work has advanced understanding of fundamental immunology and translated this understanding for the treatment of human disease with a major focus on children’s cancers. She has led numerous first-in-human and first-in-child clinical trials spanning dendritic cell vaccines, cytokines, and adoptive immunotherapy using NK cells and genetically modified T cells. Her work is credited with identifying an essential role for the thymus in human T cell regeneration (NEJM 1995) and discovering IL-7 as the master regulator of T cell homeostasis (Blood 2001, J Exp Med 2008). Her group was among the first to demonstrate impressive activity of CD19-CAR in pediatric leukemia (Lancet 2015), developed a CD22-CAR that is the only active salvage therapy for CAR19 resistant B cell malignancies (Nat Med 2018, J Clin Onc 2020, Blood 2021), demonstrated preclinical activity of GD2 targeting CARs for pediatric diffuse intrinsic pontine glioma (Nat Med 2018), demonstrated superiority of regional CNS delivery of CAR T cells for brain tumors (Nat Med 2020) and demonstrated impressive clinical activity of GD2-CAR T cells in this disease (NCT04196413), which is among the first to demonstrate significant and consistent activity of CAR T cells in solid cancers (Nature 2022). Her group identified T cell exhaustion as a major feature CAR T cell potency (Nat Med 2015), created the first exhaustion-resistance (Nature 2019) and exhaustion-reversal platforms (Science 2021) and developed a best-in-class regulatable “remote-controlled” CAR T cell platform (Cell, 2022). She serves in numerous national leadership positions, including Co-PI of a Pediatric Immunotherapy Discovery and Development Network U54 grant, and co-Leader of the St. Baldrick’s-StandUp2Cancer Pediatric Dream Team. She has received numerous awards, including election as a fellow of the AACR Academy, the Smalley Award for outstanding contributions to cancer immunotherapy from the Society for the Immunotherapy of Cancer, the AACR-St.Baldrick’s Distinguished Achievement Award for Pediatric Cancer Research, and the Nobility in Science Award from the Sarcoma Foundation of America. She has published over 250 manuscripts and her h-index in August 2022 according to google scholar is 96 and founded 3 biotech companies. Crystal is Board Certified in Pediatrics, Pediatric Hematology-Oncology and Internal Medicine.https://en.wikipedia.org/wiki/Crystal_Mackall#biotechnology #science #vc #startup #startups #startupideas #biology #biotech #chemistry #business #speech #speeches #investing #investment #lifescience #casestudy #scientist #scientists #inventors #inventor #inventions #invention #research #innovation #siliconvalley #entrepreneur #entrepreneurship #entrepreneurs #healthcare #genomics #genetics #history #biologia #technology #tech #founderstories #founder #founders #founderstory #scienceandtechnology #sciencestory #stories #bioengineering #engineering #engineer #biochemistry #discovery #discover #technical #health #education #educational #learning #learn #podcast #podcasts #podcasting #podcaster #technews Axial Newsletter: https://axial.substack.com/Build with Axial: https://axial22.axialvc.com/

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Pediatric Cancer

Ep. 266 – Coffee With Khalipa | Pack A Big Punch [Video]

Skip the decaf today and get ready to pack some punch! Did you know that you can still get a good workout in with limited equipment? Yep – you don’t need the nicest garage gym in town to get super fit. It’s all about moving large loads, long distances, quickly. Take a listen for Jason’s favorite minimal equipment movement!Jason is the founder of NCFIT, a global fitness company with brick and mortar locations, corporate wellness, and digital services. He is a 3x Team USA CrossFit member and CrossFit Games Champion. A Pediatric Cancer Advocate after his daughter was diagnosed with Leukemia in 2016, host of the Effort Over Everything Podcast, and BJJ Purple Belt.Find Jason Here:IG: https://www.instagram.com/jasonkhalipa/Podcast: https://www.nc.fit/edit/podcasts/effort-over-everythingNCFIT Website: https://www.nc.fit/ NCFIT Collective: https://www.ncfitcollective.fit/Philanthropy: https://avaskitchen.org/

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Pediatric Cancer

Little Heroes Blood Drives [Video]

This year Shawn Flynn has helped organize over 50 blood drives in the month of September to raise awareness for Pediatric Cancer. His goal is to get over 1000 donors and raise $10,000 for the Isabella Santos Foundation. When you donate at a Little Heroes Blood Drive, OneBlood will donate $10 to ISF for Pediatric Cancer Research and you’ll receive a limited edition Little Heroes T-shirt. To find a little heroes blood drive, visit: www.oneblood.org/littleheroes

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Pediatric Cancer

Childhood Cancer Treatments [Video]

Pediatric cancer differs from adult cancer in terms of treatment options, and many experts in childhood cancer can help parents navigate the best route for their families. There are many different forms of treatment, including chemotherapy, surgery, immunotherapy, radiation therapy, or stem cell treatments. In some cases, a child may undergo a combination of different types of treatment. Many clinical trials are also conducted for children and adolescents in an attempt to find more effective therapy options. St. Jude’s Children’s Research Hospital continues to advocate for childhood cancer treatments and has increased the survival rate from 20% to 80% since beginning its work over 50 years ago. Their goal is to eliminate the loss of life due to cancer in children. Treatment can have very different effects on children compared to adults. Because children and adolescents are still growing, the treatment received for cancer may respond differently as they age.Read more about childhood cancer on our website:https://tiltonstherapyfortots.com/resources/childhood-cancer

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Pediatric Cancer

September is Childhood Cancer Awareness Month [Video]

When Shawn Flynn started the Little Heroes Blood Drives, he put a call out to the Childhood Cancer Community and they answered.This year, we are hosting over 50 blood drives to meet our goal of 1000 donors! With every successful donation at a Little Heroes Blood Drive, OneBlood will donate $10 to the Isabella Santos Foundation. Pediatric cancer is notoriously underfunded and rare pediatric cancers get even less, the Isabella Santos Foundation is dedicated to improving rare pediatric cancer treatment options in an effort to increase survival rates of kids with cancer. 💜 To learn how to get involved or find a Little Heroes Blood Drive, visit www.OneBlood.org/littleheroes#beatgrowlive

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Pediatric Cancer

Fighting Rare Pediatric Cancer at Miami Cancer Institute: Remission is Greatest Gift, Says Mom of 8-Year-Old Maddie [Video]

At 8, Maddison Maddie Nuez clearly recalls the impact of hearing medical news at the age of 4 that would sharply disrupt her young life. She was diagnosed in 2018 with acute lymphocytic leukemia (ALL) a type of cancer of the blood and bone marrow. At the age of 4, she was treated at Baptist Health Miami Cancer Institute.

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Pediatric Cancer

Curing the Incurable: The Crazy 8 Initiative Projects [Video]

Learn more about the Crazy 8 Projects: www.AlexsLemonade.org/Crazy-8-Initiative-ProjectsAlex’s Lemonade Stand Foundation founder Alex Scott believed that if we all work together, we would find cures for childhood cancer. As researchers continue to move closer to cures for all children, there are still types of childhood cancer that continue to be incurable. In the spirit of Alex’s legacy, Alex’s Lemonade Stand Foundation has committed $18.5 million to four game-changing, collaborative projects at 15 institutions in the United States and Europe. Funded through the Crazy 8 Initiative, these projects are taking on the most deadly childhood cancers with one singular focus: curing the incurable.“This is a high-risk project. You cannot just neglect these problems—and say okay, we’ve tried for such a long time and we can’t do anything about it. That’s not helping the kids. You have to take the risk.” – Dr. Heinrich Kovar, Crazy 8 Awardee

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Pediatric Cancer

Childhood Cancer in Telugu | Pediatric Oncologist | Dr. Neema Bhat | Healius Cancer & Hematology [Video]

Any age might be distressed by receiving a cancer diagnosis, but children are especially vulnerable. It’s normal to have many inquiries, such as a lot of inquiries, such Who should treat my child? Will my kid recover? What does this entail for our family, exactly? The informational movie offers a starting point for understanding the fundamentals of pediatric cancer, albeit not all queries have answers.Dr. Neema BhatMBBS, MD (USA), FAAP (USA)Senior ConsultantHematology, BMT Physician, & Pediatric Oncology Healius Cancer & Hematology clinics, a new ray of hope. Healius cancer & hematology is cancer hospital in Bangalore. From the humble beginnings, we have come a long way to bring world class cancer care to thousands.Healius cancer & hematology is dedicated to cancer awareness, prevention, screening, and treatments. Healius cancer & hematology provides the best specialists across all types of cancer care. Cancer treatment in India is made easy with Healius cancer & hematology clinics, as we are teamed-up with speciality doctors who serve for best cancer treatment.For Appointments Call on : (+91) 99006 13143Visit: https://healiuscancerhematology.com/Facebook: https://www.facebook.com/HealiuscancerInstagram: https://www.instagram.com/healiuscancer/Twitter: https://twitter.com/HealiuscancerLinkedIn: http://linkedin.com/company/healius-cancer-hematology-clinics#childhoodcancer #childhoodcancerawarness #leukemia #childhoodcancerintelugu #pediatriccancer #cancerinchildren #cancerinkids #cancerawarness #chemotherapy #drneemabhat #healiuscancerhematology

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Pediatric Cancer

The Leukemia & Lymphoma Society celebrates 70-year legacy by launching new LLS Childrens Initiative, to accelerate new and better treatments for pediatric blood cancers Ethical Marketing News [Video]

As an organization founded by a family for families, The Leukemia & Lymphoma Society (LLS) is celebrating 70 years of impact on generations of families, researchers and volunteers while looking to the future by redoubling its commitment to improve treatments and care for children with cancer.