Defense: Argument for Anti-LAG3-based Frontline Combination ICI Treatment of Stage IV Melanoma [Video]

Host: Jeffrey S. Weber, MD, PhD

Host: Jason J. Luke, MD, FACP

Host: Ryan Sullivan, MD

Host: Sapna Patel, MD

Despite improved prognosis for melanoma patients due to advances in treatment options in recent years, survival rates for patients with metastatic disease remain low. With two mechanistically different immune checkpoint inhibitor combinations available, it is critical that clinicians be able to differentiate among currently approved regimens to inform frontline treatment selection in different patient populations. The crucial question revolves around which target, anti-CTLA-4 versus anti-LAG3, provides the greatest benefit in metastatic melanoma when combined with a PD-1 inhibitor.Report with a jury of your peers to debate the optimal frontline treatment approach for a patient with unresectable stage IV BRAF-wild type melanoma. View the persuasive evidence and listen to expert witnesses defend the pros and cons for this vulnerable patient population. Cast your polling vote as the case proceeds. We’ll see you in court to render a verdict in an important case with implications for your clinical practice!